All Phenotypes Tex101<tm1Osb> MGI Mouse

reproductive system phenotype ( J:197323 )

N	• testis weights and histology are normal • spermatozoa are morphologically normal • mating behavior, ejaculation, and vaginal plug formation are all normal

• defect in the ability of sperm to migrate into the oviduct

• capacitated sperm deposited directly into the oviduct fertilize eggs normally

• percentage of hyperactivated spermatozoa is higher than in wild-type cells

• however, sperm motility is normal

male infertility ( J:197323 )

abnormal acrosome reaction ( J:197323 )

• ratio of acrosome-reacted and acrosome intact spermatozoa is normal for the first 90 min of incubation but increased after 180 min of incubation

• despite frequent collisions, zona binding ability of spermatozoa to cumulus free eggs is nearly lost

• fertilizing ability is normal when cumulus-intact eggs are used

behavior/neurological phenotype ( J:197323 )

N	• mating behavior is normal

• defect in the ability of sperm to migrate into the oviduct

• capacitated sperm deposited directly into the oviduct fertilize eggs normally

• percentage of hyperactivated spermatozoa is higher than in wild-type cells

• however, sperm motility is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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