All Phenotypes Tex101<tm1Osb> MGI Mouse

reproductive system phenotype ( J:197323 )

N	• testis weights and histology are normal • spermatozoa are morphologically normal • mating behavior, ejaculation, and vaginal plug formation are all normal

• defect in the ability of sperm to migrate into the oviduct

• capacitated sperm deposited directly into the oviduct fertilize eggs normally

• percentage of hyperactivated spermatozoa is higher than in wild-type cells

• however, sperm motility is normal

male infertility ( J:197323 )

abnormal acrosome reaction ( J:197323 )

• ratio of acrosome-reacted and acrosome intact spermatozoa is normal for the first 90 min of incubation but increased after 180 min of incubation

• despite frequent collisions, zona binding ability of spermatozoa to cumulus free eggs is nearly lost

• fertilizing ability is normal when cumulus-intact eggs are used

behavior/neurological phenotype ( J:197323 )

N	• mating behavior is normal

• defect in the ability of sperm to migrate into the oviduct

• capacitated sperm deposited directly into the oviduct fertilize eggs normally

• percentage of hyperactivated spermatozoa is higher than in wild-type cells

• however, sperm motility is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/12/2024 MGI 6.13