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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnao1tm2Rneu
targeted mutation 1, Richard R Neubig
MGI:5508226
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gnao1tm2Rneu/Gnao1tm2Rneu involves: 129S1/Sv * C57BL/6J MGI:5508313
ht2
Gnao1tm2Rneu/Gnao1+ B6.129S1-Gnao1tm2Rneu MGI:6295359
ht3
Gnao1tm2Rneu/Gnao1+ involves: 129S1/Sv * C57BL/6J MGI:5508325


Genotype
MGI:5508313
hm1
Allelic
Composition
Gnao1tm2Rneu/Gnao1tm2Rneu
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation (0 available); any Gnao1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are not viable




Genotype
MGI:6295359
ht2
Allelic
Composition
Gnao1tm2Rneu/Gnao1+
Genetic
Background
B6.129S1-Gnao1tm2Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation (0 available); any Gnao1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• both males and females show reduced activity in the first 10 min of the open field arena indicating decreased activity in a novel environment
• females exhibit a reduced retention time on the accelerating rotarod, while males are unaffected
• however, mice do not show a difference in learning rate on the rotarod
• females, but not males, show reduced forepaw grip strength
• females exhibit abnormal gait with reduced stride length and increased paw angle variability while males only show increased paw angle variability
• females show reduced stride length
• mice exhibit reduced activity in the open field arena, with both males and females showing reduced activity in the first 10 minutes (novel environment), and females, but not males, showing reduced activity in the next 10-30 min designated as sustained activity
• both males and females show reduced total activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
developmental and epileptic encephalopathy 17 DOID:0080450 OMIM:615473
J:271137




Genotype
MGI:5508325
ht3
Allelic
Composition
Gnao1tm2Rneu/Gnao1+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation (0 available); any Gnao1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice treated with epinephrine exhibit enhanced reduction in burst frequency of induced epileptiform activity compared with control mice

nervous system
• mice treated with epinephrine exhibit enhanced reduction in burst frequency of induced epileptiform activity compared with control mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory