Phenotypes associated with this allele

• Allele Symbol: Prmt6^tm1.2Rchd
• Allele Name: targeted mutation 1.2, Stephane Richard
• Allele ID: MGI:5508653
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prmt6^tm1.2Rchd/Prmt6^tm1.2Rchd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N	MGI:5508659
cx2	Prmt6^tm1.2Rchd/Prmt6^tm1.2Rchd Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N	MGI:5509171

Genotype
MGI:5508659

hm1

• Allelic Composition: Prmt6^tm1.2Rchd/Prmt6^tm1.2Rchd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:199753 )

• mouse embryonic fibroblasts exhibit an increase in G0/G1 and decrease in S phase compared with wild-type cells

decreased fibroblast proliferation ( J:199753 )

• at early passages in mouse embryonic fibroblasts

• infection with a retrovirus expression a catalytically inactive mutant form of the gene fails to rescue proliferation unlike the full length version

early cellular replicative senescence ( J:199753 )

• in mouse embryonic fibroblasts

Genotype
MGI:5509171

cx2

• Allelic Composition: Prmt6^tm1.2Rchd/Prmt6^tm1.2Rchd; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * FVB/N

cellular

cellular phenotype ( J:199753 )

N • mouse embryonic fibroblasts exhibit normal senescence