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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rc3h2tm1.2Cgv
targeted mutation 1.2, Carola Vinuesa
MGI:5508928
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv involves: C57BL/6 MGI:5509048
cx2
 		Rc3h1san/Rc3h1san
Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv 		involves: C57BL/6 * C57BL/6JSfdAnu MGI:5509049


Genotype
MGI:5509048
hm1
Allelic
Composition		 Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h2tm1.2Cgv mutation (1 available); any Rc3h2 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:196137 )
N
• homozygotes are viable and do not over express ICOS
• effector and memory CD4+ cells, T follicular helper cells all normal
• germinal centers all normal
increased macrophage cytokine production ( J:196137 )
• increased portion of macrophage producing TNF
increased tumor necrosis factor secretion ( J:196137 )
• increased TNF expression in macrophage and splenic cells

hematopoietic system
increased macrophage cytokine production ( J:196137 )
• increased portion of macrophage producing TNF




Genotype
MGI:5509049
cx2
Allelic
Composition		 Rc3h1san/Rc3h1san
Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic
Background		 involves: C57BL/6 * C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1san mutation (7 available); any Rc3h1 mutation (42 available)
Rc3h2tm1.2Cgv mutation (1 available); any Rc3h2 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:196137 )
• premature and fully penetrant mortality before 22 weeks of age

immune system
increased T follicular helper cell number ( J:196137 )
• elevated percentage of Tfh cells
increased circulating tumor necrosis factor level ( J:196137 )
• 100 fold increase in TNF levels in mice surviving low doses of LPS
increased inflammatory response ( J:196137 )
• more sever inflammatory infiltrates of many organs
kidney inflammation ( J:196137 )
• more sever inflammatory infiltrates
increased susceptibility to bacterial infection ( J:196137 )
• increased susceptibility to low doses of lipopolysaccharide
• three of four died of low doses which are not lethal to mice homozygous for a single mutation

hematopoietic system
increased T follicular helper cell number ( J:196137 )
• elevated percentage of Tfh cells

renal/urinary system
kidney inflammation ( J:196137 )
• more sever inflammatory infiltrates

homeostasis/metabolism
increased circulating tumor necrosis factor level ( J:196137 )
• 100 fold increase in TNF levels in mice surviving low doses of LPS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory