About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rc3h2tm1.2Cgv
targeted mutation 1.2, Carola Vinuesa
MGI:5508928
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv involves: C57BL/6 MGI:5509048
cx2
 		Rc3h1san/Rc3h1san
Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv 		involves: C57BL/6 * C57BL/6JSfdAnu MGI:5509049


Genotype
MGI:5509048
hm1
Allelic
Composition		 Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h2tm1.2Cgv mutation (1 available); any Rc3h2 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:196137 )
N
• homozygotes are viable and do not over express ICOS
• effector and memory CD4+ cells, T follicular helper cells all normal
• germinal centers all normal
increased macrophage cytokine production ( J:196137 )
• increased portion of macrophage producing TNF
increased tumor necrosis factor secretion ( J:196137 )
• increased TNF expression in macrophage and splenic cells

hematopoietic system
increased macrophage cytokine production ( J:196137 )
• increased portion of macrophage producing TNF




Genotype
MGI:5509049
cx2
Allelic
Composition		 Rc3h1san/Rc3h1san
Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
Genetic
Background		 involves: C57BL/6 * C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1san mutation (7 available); any Rc3h1 mutation (42 available)
Rc3h2tm1.2Cgv mutation (1 available); any Rc3h2 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:196137 )
• premature and fully penetrant mortality before 22 weeks of age

immune system
increased T follicular helper cell number ( J:196137 )
• elevated percentage of Tfh cells
increased circulating tumor necrosis factor level ( J:196137 )
• 100 fold increase in TNF levels in mice surviving low doses of LPS
increased inflammatory response ( J:196137 )
• more sever inflammatory infiltrates of many organs
kidney inflammation ( J:196137 )
• more sever inflammatory infiltrates
increased susceptibility to bacterial infection ( J:196137 )
• increased susceptibility to low doses of lipopolysaccharide
• three of four died of low doses which are not lethal to mice homozygous for a single mutation

hematopoietic system
increased T follicular helper cell number ( J:196137 )
• elevated percentage of Tfh cells

renal/urinary system
kidney inflammation ( J:196137 )
• more sever inflammatory infiltrates

homeostasis/metabolism
increased circulating tumor necrosis factor level ( J:196137 )
• 100 fold increase in TNF levels in mice surviving low doses of LPS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory