About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Uba6tm1Whpr
targeted mutation 1, Wade Harper
MGI:5509054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Uba6tm1Whpr/Uba6tm1Whpr involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac MGI:5470303
cn2
Uba6tm1Whpr/Uba6tm1Whpr
Tg(Nes-cre)1Kln/0
B6.Cg-Uba6tm1Whpr Tg(Nes-cre)1Kln MGI:5511126


Genotype
MGI:5470303
hm1
Allelic
Composition
Uba6tm1Whpr/Uba6tm1Whpr
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba6tm1Whpr mutation (1 available); any Uba6 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5511126
cn2
Allelic
Composition
Uba6tm1Whpr/Uba6tm1Whpr
Tg(Nes-cre)1Kln/0
Genetic
Background
B6.Cg-Uba6tm1Whpr Tg(Nes-cre)1Kln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Uba6tm1Whpr mutation (1 available); any Uba6 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a quarter of mice that survive to P21 die within 2 months
• however, lethality is partially rescued by making food more accessible
• half of mice die between P5 and P21

behavior/neurological
• with altered response to an aversive stimulus
• in the Y-maze test
• absence of stomach content in several mice at death
• in a forced swim test, mice spend less time immobilized compared with wild-type mice
• constitutive without an alteration in body temperature
• slightly better performance on a rotarod
• in a novel environment with a lack of habituation
• pronounced in the dark phase
• aversion to nesting
• mice prefer to explore an empty chamber rather than a stranger mouse

nervous system
N
• neuronal apoptosis at E14.5 and P5 is normal
• reduced density in the CA3 region and amygdala
• in the CA3 region as early as P5, the basolateral amygdala and piriform cortex
• however, the number of neurons is normal in the CA1, dentate gyrus, cortex and cerebellar regions

homeostasis/metabolism
N
• mice exhibit normal body temperature and constant respiratory exchange ratio throughout the diurnal cycle
• hypermetabolic

growth/size/body
• at birth and 11 weeks





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory