Allele Symbol Allele Name Allele ID |
Uba6tm1Whpr targeted mutation 1, Wade Harper MGI:5509054 |
||||||||||||
Summary |
2 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• a quarter of mice that survive to P21 die within 2 months
• however, lethality is partially rescued by making food more accessible
|
• half of mice die between P5 and P21
|
• with altered response to an aversive stimulus
|
• lack of habituation
|
• in the Y-maze test
|
• in a forced swim test, mice spend less time immobilized compared with wild-type mice
|
• constitutive without an alteration in body temperature
|
• slightly better performance on a rotarod
|
• in a novel environment with a lack of habituation
• pronounced in the dark phase
|
• aversion to nesting
|
• mice prefer to explore an empty chamber rather than a stranger mouse
|
N |
• neuronal apoptosis at E14.5 and P5 is normal
|
• scattered neurons
|
• reduced density in the CA3 region and amygdala
|
• in the CA3 region as early as P5, the basolateral amygdala and piriform cortex
• however, the number of neurons is normal in the CA1, dentate gyrus, cortex and cerebellar regions
|
N |
• mice exhibit normal body temperature and constant respiratory exchange ratio throughout the diurnal cycle
|
• hypermetabolic
|
• at birth and 11 weeks
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|