Phenotypes associated with this allele

• Allele Symbol: Rc3h2^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5509140
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rc3h2^tm1c(KOMP)Wtsi/Rc3h2^tm1c(KOMP)Wtsi Tg(Cd4-cre)1Cwi/?	involves: C57BL/6N * DBA/2	MGI:5510238
cn2	Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Rc3h2^tm1c(KOMP)Wtsi/Rc3h2^tm1c(KOMP)Wtsi Tg(Cd4-cre)1Cwi/?	involves: C57BL/6N * DBA/2	MGI:5510239

Genotype
MGI:5510238

cn1

• Allelic Composition: Rc3h2^{tm1c(KOMP)Wtsi}/Rc3h2^{tm1c(KOMP)Wtsi}; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: C57BL/6N * DBA/2
• Cell Lines: EPD0131_2_B09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:196136 )

N • normal thymocyte development

N • T follicular helper cell frequency is similar to controls

Genotype
MGI:5510239

cn2

• Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass; Rc3h2^{tm1c(KOMP)Wtsi}/Rc3h2^{tm1c(KOMP)Wtsi}; Tg(Cd4-cre)1Cwi/?
• Genetic Background: involves: C57BL/6N * DBA/2
• Cell Lines: EPD0131_2_B09

immune system

abnormal immune system cell morphology ( J:196136 )

abnormal B cell number ( J:196136 )

• B220+ B cells are almost undetectable

• spleens often with reduced B cell counts

increased germinal center B cell number ( J:196136 )

increased T follicular helper cell number ( J:196136 )

• both frequency and absolute numbers are increased

decreased T cell number ( J:196136 )

decreased CD4-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in total cell numbers for CD4+ cells

• significant decrease in naive CD4+ T cell numbers

decreased CD8-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in naive CD8+ T cell numbers

abnormal immune system organ morphology ( J:196136 )

abnormal spleen morphology ( J:196136 )

enlarged spleen ( J:196136 )

• splemomegaly at a young age

abnormal spleen B cell follicle morphology ( J:196136 )

• unorganized or absent follicular structures in the spleen

abnormal spleen periarteriolar lymphoid sheath morphology ( J:196136 )

• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells

enlarged lymph nodes ( J:196136 )

• at a young age

abnormal immune system physiology ( J:196136 )

• severe immune dysregulation

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells

hematopoietic system

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells

abnormal B cell number ( J:196136 )

• B220+ B cells are almost undetectable

• spleens often with reduced B cell counts

increased germinal center B cell number ( J:196136 )

increased T follicular helper cell number ( J:196136 )

• both frequency and absolute numbers are increased

decreased T cell number ( J:196136 )

decreased CD4-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in total cell numbers for CD4+ cells

• significant decrease in naive CD4+ T cell numbers

decreased CD8-positive, alpha-beta T cell number ( J:196136 )

• significant decrease in naive CD8+ T cell numbers

abnormal spleen morphology ( J:196136 )

enlarged spleen ( J:196136 )

• splemomegaly at a young age

abnormal spleen B cell follicle morphology ( J:196136 )

• unorganized or absent follicular structures in the spleen

abnormal spleen periarteriolar lymphoid sheath morphology ( J:196136 )

• T cell areas of the spleen are unorganized, particularly those affecting CD8+ cells

growth/size/body

enlarged spleen ( J:196136 )

• splemomegaly at a young age

cellular

increased T cell proliferation ( J:196136 )

• increased activation of both CD4+ and CD8+ T cells