Phenotypes associated with this allele

• Allele Symbol: Arpc3^tm1Ssod
• Allele Name: targeted mutation 1, Scott H Soderling
• Allele ID: MGI:5509154
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arpc3^tm1Ssod/Arpc3^tm1Ssod	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:5509190
cn2	Arpc3^tm1Ssod/Arpc3^tm1Ssod Tg(Camk2a-cre)T29-1Stl/0	involves: 129S6/SvEvTac * BALB/c * C57BL	MGI:5509191
cn3	Arpc3^tm1Ssod/Arpc3^tm1Ssod Gt(ROSA)26Sor^tm2(CAG-tdTomato)Fawa/Gt(ROSA)26Sor^+ Tg(Thy1-cre/ERT2,-EYFP)VGfng/0	involves: C57BL/6 * SJL	MGI:5509192

Genotype
MGI:5509190

cn1

• Allelic Composition: Arpc3^tm1Ssod/Arpc3^tm1Ssod
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus pyramidal cell morphology ( J:196577 )

• after photobleaching, actin filament turnover in the dendritic spines of CA1 pyramidal neurons transfected with GFP-cre adenovirus is retarded compared to in control cells

• however, basal levels of actin is normal

abnormal dendritic spine morphology ( J:196577 )

• neurons infected with GFP-cre completely lack the sustained phase of structural plasticity in spines compared with controls

• however, activity-dependent spine shrinkage is normal in cre-treated neurons

Genotype
MGI:5509191

cn2

• Allelic Composition: Arpc3^tm1Ssod/Arpc3^tm1Ssod; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL

behavior/neurological

behavior/neurological phenotype ( J:196577 )

N • mice exhibit normal basal startle responses

abnormal object recognition memory ( J:196577 )

• in a novel object recognition test, adolescent and adult mice exhibit disrupted episodic learning and memory compared with control mice

• early and pronounced deficit in short-term, long-term and remote memory in a novel object recognition test

impaired long-term object recognition memory ( J:196577 )

• impaired in adolescent and adult mice in a novel object recognition test

impaired short-term object recognition memory ( J:196577 )

• impaired in adolescent and adult mice in a novel object recognition test

abnormal spatial working memory ( J:196577 )

• impaired in adult, but not adolescent, mice in a Y-maze

hyperactivity ( J:196577 )

• adult, but not adolescent, mice in the home cage

increased vertical activity ( J:196577 )

• in adult, but not adolescent, mice

increased stereotypic behavior ( J:196577 )

• in adult, but not adolescent, mice

abnormal social/conspecific interaction behavior ( J:196577 )

• reduced social interaction of in adult, but not adolescent, mice

nervous system

abnormal dendritic spine morphology ( J:196577 )

• progressive loss of spine at P120

• neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons

abnormal synapse morphology ( J:196577 )

• at 4 months, mice exhibit a loss of synapses onto spines in the stratum radiatum of the hippocampus and cerebral cortex compared with control mice

decreased prepulse inhibition ( J:196577 )

• in adolescent and adult mice

Genotype
MGI:5509192

cn3

• Allelic Composition: Arpc3^tm1Ssod/Arpc3^tm1Ssod; Gt(ROSA)26Sor^{tm2(CAG-tdTomato)Fawa}/Gt(ROSA)26Sor⁺; Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

abnormal dendritic spine morphology ( J:196577 )

• by 4 and 8 weeks after tamoxifen treatment, neurons exhibit a progressive reduction of spine density in the stratum radiatum compared with control neurons

• tamoxifen-treated neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons