Phenotypes associated with this allele

• Allele Symbol: Tg(T-cre/ERT2)1Lwd
• Allele Name: transgene insertion 1, Mark Lewandoski
• Allele ID: MGI:5509185
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(T-cre/ERT2)1Lwd/0	involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr	MGI:5509196
tg2	Tg(T-cre/ERT2)1Lwd/Tg(T-cre/ERT2)1Lwd	involves: C3H/HeNCr * C57BL/6NCr	MGI:5509197

Genotype
MGI:5509196

cn1

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(T-cre/ERT2)1Lwd/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

caudal body truncation ( J:200549 )

• with tamoxifen administration at E6.5, E8.5 embryos phenocopy the caudal body truncation seen with constitutive T-cre mediated inactivation

abnormal axial mesoderm morphology ( J:200549 )

• with tamoxifen administration at E8.5, E10.5 embryos show defects in depletion of pre-somitic mesoderm (PSM) and segmentation defects, similar to embryos at E8.5

abnormal somite development ( J:200549 )

• with tamoxifen administration at E6.5 or E8.5, E8.5 and E10.5 embryos show disruption of somite patterning

Genotype
MGI:5509197

tg2

• Allelic Composition: Tg(T-cre/ERT2)1Lwd/Tg(T-cre/ERT2)1Lwd
• Genetic Background: involves: C3H/HeNCr * C57BL/6NCr

normal phenotype

no abnormal phenotype detected ( J:200549 )

• homozygotes show no obvious defects in health or fertility