Phenotypes associated with this allele

• Allele Symbol: Prx^tm2.1Brp
• Allele Name: targeted mutation 2.1, Peter Brophy
• Allele ID: MGI:5509222
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prx^tm2.1Brp/Prx^tm2.1Brp	B6.129P2-Prx^tm2.1Brp	MGI:5509301

Genotype
MGI:5509301

hm1

• Allelic Composition: Prx^tm2.1Brp/Prx^tm2.1Brp
• Genetic Background: B6.129P2-Prx^tm2.1Brp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent Cajal-Retzius cell ( J:199744 )

abnormal Schwann cell morphology ( J:199744 )

• reduced elongation

increased Schwann cell number ( J:199744 )

• in older mice

abnormal internode morphology ( J:199744 )

• shorter intermodal lengths at 3, 6 and 16 weeks

abnormal myelination ( J:199744 )

• older mice exhibit very mild disturbances in myelination such as onion bulb profiles with supernumerary Schwann cells compared with control mice

• older mice exhibit increased number of Schmidt-Lanterman incisures compared with control cells

• however, young mice exhibit normal

abnormal nerve conduction ( J:199744 )

• retarded development of maximum value

decreased nerve conduction velocity ( J:199744 )

• at 3 and 6 weeks

• however, conduction velocity is normal by 16 weeks

behavior/neurological

behavior/neurological phenotype ( J:199744 )

N • at 16 weeks, mice exhibit normal hind paw withdrawal response after mechanical stimulation or noxious thermal stimulation

impaired coordination ( J:199744 )

• at 3, but not 16, weeks

integument

integument phenotype ( J:199744 )

N • at 16 weeks, mice exhibit normal hind paw withdrawal response after mechanical stimulation or noxious thermal stimulation