Phenotypes associated with this allele

• Allele Symbol: Mboat7^tm1Arai
• Allele Name: targeted mutation 1, Hiroyoki Arai
• Allele ID: MGI:5509338
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mboat7^tm1Arai/Mboat7^tm1Arai	B6.129P2-Mboat7^tm1Arai	MGI:5509355

Genotype
MGI:5509355

hm1

• Allelic Composition: Mboat7^tm1Arai/Mboat7^tm1Arai
• Genetic Background: B6.129P2-Mboat7^tm1Arai

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:200247 )

• some mice die in the 4 weeks after birth

perinatal lethality, incomplete penetrance ( J:200247 )

• some mice die between E18.5 and P0

postnatal lethality, incomplete penetrance ( J:200247 )

• some mice die in the 4 weeks after birth

nervous system

nervous system phenotype ( J:200247 )

N • normal midbrain size at E18.5

increased neuron apoptosis ( J:200247 )

• in the cortex

abnormal neuron differentiation ( J:200247 )

• reduced neurite outgrowth in the hippocampal neurons

• however, neurogenesis is normal

abnormal neuronal migration ( J:200247 )

• at E18.5, Brn1+ neurons are stacked in the intermediate zone unlike in wild-type mice

• palisade-like neuronal processes are disordered in the cortex and the subplate neurons

• neuronal migration is delayed

forebrain hypoplasia ( J:200247 )

• at E18.5

abnormal hippocampus morphology ( J:200247 )

• disarranged laminar structure

small hippocampus ( J:200247 )

abnormal cerebral cortex morphology ( J:200247 )

• reduced with disarranged laminar structure

• palisade-like neuronal processes are disordered in the cortex and the subplate neurons

abnormal neurite morphology ( J:200247 )

• reduced neurite outgrowth in the hippocampal neurons

homeostasis/metabolism

decreased fatty acids level ( J:200247 )

• decreased arachidonic acid in total phospatidylinositol fatty acid in the brain

increased fatty acids level ( J:200247 )

• increased palmitic acid and docosahexaenoic acid in total phospatidylinositol fatty acid in the brain

growth/size/body

decreased body size ( J:200247 )

cellular

increased neuron apoptosis ( J:200247 )

• in the cortex

abnormal neuron differentiation ( J:200247 )

• reduced neurite outgrowth in the hippocampal neurons

• however, neurogenesis is normal

abnormal neuronal migration ( J:200247 )

• at E18.5, Brn1+ neurons are stacked in the intermediate zone unlike in wild-type mice

• palisade-like neuronal processes are disordered in the cortex and the subplate neurons

• neuronal migration is delayed