Phenotypes associated with this allele

• Allele Symbol: Setd5^tm1.1Mgn
• Allele Name: targeted mutation 1.1, Mark Magnuson
• Allele ID: MGI:5509467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setd5^tm1.1Mgn/Setd5^tm1.1Mgn	involves: 129S6/SvEvTac * CD-1	MGI:6281599

Genotype
MGI:6281599

hm1

• Allelic Composition: Setd5^tm1.1Mgn/Setd5^tm1.1Mgn
• Genetic Background: involves: 129S6/SvEvTac * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:237500 )

• lack of embryonic blood vessels contained (only maternal blood vessels with mature erythrocytes) at age E9.5

abnormal vascular development ( J:237500 )

• lack of or severely reduced cardiac myosin heavy chain expression in dorsal aorta at age E9.5

abnormal vascular plexus formation ( J:237500 )

• abnormally dilated capillary yolk sac plexus at age E9.5

abnormal vitelline vasculature morphology ( J:237500 )

• pale yolk sac with fewer blood vessels at age E9.5

disorganized yolk sac vascular plexus ( J:237500 )

• at age E9.5

abnormal heart morphology ( J:237500 )

• no beating heart in around 50% of embryos at age E9.5

abnormal myocardium layer morphology ( J:237500 )

• at age E9.5

• thin myocardium

• no contact with endocardium

• large gap with pericardium

abnormal myocardial trabeculae morphology ( J:237500 )

• reduced trabeculation in the existing single ventricle at age E9.5

enlarged heart ( J:237500 )

• swollen hearts at age E9.5

pericardial effusion ( J:237500 )

• up to age E10.5

hemorrhage ( J:237500 )

• widespread hemorrhage at age E10.5

embryo

abnormal vitelline vasculature morphology ( J:237500 )

• pale yolk sac with fewer blood vessels at age E9.5

disorganized yolk sac vascular plexus ( J:237500 )

• at age E9.5

increased embryonic tissue cell apoptosis ( J:237500 )

• apoptotic cell number increase from 4% to 25% at age E9.5 according to activated Caspase 3 measurements

embryonic growth retardation ( J:237500 )

• underdeveloped at age E10.5

• smaller and fewer somites at age E9.5, often showing lack of neural tube closure

decreased embryo size ( J:237500 )

• at ages E9.5 and E10.5

abnormal somite development ( J:237500 )

• fewer somites at age E9.5

• lack of or severely reduced cardiac myosin heavy chain expression in somites at age E9.5

abnormal tail bud morphology ( J:237500 )

• tail effusions (swelling due to fluid buildup) up to age E10.5

abnormal placenta morphology ( J:237500 )

• embryonic blood vessels remain in chorioallantoic region, did not invade labyrinthine layer, at age E9.5

abnormal placenta labyrinth morphology ( J:237500 )

• significantly thinner at age E9.5

abnormal placental labyrinth vasculature morphology ( J:237500 )

• lack of embryonic blood vessels contained (only maternal blood vessels with mature erythrocytes) at age E9.5

muscle

abnormal myocardium layer morphology ( J:237500 )

• at age E9.5

• thin myocardium

• no contact with endocardium

• large gap with pericardium

abnormal myocardial trabeculae morphology ( J:237500 )

• reduced trabeculation in the existing single ventricle at age E9.5

growth/size/body

enlarged heart ( J:237500 )

• swollen hearts at age E9.5

embryonic growth retardation ( J:237500 )

• underdeveloped at age E10.5

• smaller and fewer somites at age E9.5, often showing lack of neural tube closure

decreased embryo size ( J:237500 )

• at ages E9.5 and E10.5

hematopoietic system

hematopoietic system phenotype ( J:237500 )

N • normal definitive hematopoiesis at age E9.5 according to Itga2b expression

homeostasis/metabolism

pericardial effusion ( J:237500 )

• up to age E10.5

limbs/digits/tail

abnormal tail bud morphology ( J:237500 )

• tail effusions (swelling due to fluid buildup) up to age E10.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:237500 )

• no viable embryos beyond age E10.5

cellular

increased embryonic tissue cell apoptosis ( J:237500 )

• apoptotic cell number increase from 4% to 25% at age E9.5 according to activated Caspase 3 measurements