Phenotypes associated with this allele

• Allele Symbol: Tpm3^tm3Pgun
• Allele Name: targeted mutation 3, Peter Gunning
• Allele ID: MGI:5509478
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpm3^tm3Pgun/Tpm3^tm3Pgun	involves: 129S1/Sv * 129X1/SvJ	MGI:5510118

Genotype
MGI:5510118

hm1

• Allelic Composition: Tpm3^tm3Pgun/Tpm3^tm3Pgun
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle morphology ( J:200893 )

• T-tubule dysmorphology with altered function

• however, mice exhibit normal muscle fiber type

abnormal muscle contractility ( J:200893 )

• increased specific twitch force but not maximum tetanic force

• decreased time-to-peak twitch force

• potentiation of T-system depolarization

• decreased force rundown with repeated T-tubule depolarization

• however, relaxation rate is normal