Phenotypes associated with this allele

• Allele Symbol: Selenon^tm1Begg
• Allele Name: targeted mutation 1, Alan H Beggs
• Allele ID: MGI:5510170
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenon^tm1Begg/Selenon^tm1Begg	involves: C57BL/6 * C57BL/6NTac	MGI:5510235

Genotype
MGI:5510235

hm1

• Allelic Composition: Selenon^tm1Begg/Selenon^tm1Begg
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung development ( J:197753 )

abnormal pulmonary alveolar sac morphology ( J:197753 )

• alveolar chord length is increased indicating an increase in alveolar space in unstressed or stressed mice that is not rescued by N-acetyl cysteine treatment

abnormal respiratory system physiology ( J:197753 )

• increased apoptosis in alveolar septal cells

• however, baseline Newtonian resistance which reflects central airway resistance is normal

decreased lung elastance ( J:197753 )

abnormal lung volume ( J:197753 )

• the pressure-volume curves have a left shift with increased volume for a given pressure compared with wild-type mice

increased lung compliance ( J:197753 )

muscle

abnormal skeletal muscle morphology ( J:197753 )

• core lesions following induced oxidative stress (dietary vitamin E deficiency and/or running exercise)

• muscle fibers exhibit decreased ryanodine receptor-sensitive calcium release in response to caffeine

• however, cyclopiazonic acid (CPA)-evoked calcium released is normal

skeletal muscle hypertrophy ( J:197753 )

• of type 2b myofibers in response to oxidative stress

behavior/neurological

decreased vertical activity ( J:197753 )

• in exercised or unexercised mice fed a vitamin E deficient diet

• however, activity in mice fed standard chow is normal

decreased locomotor activity ( J:197753 )

• in exercised or unexercised mice fed a vitamin E deficient diet

• however, activity in mice fed standard chow is normal

homeostasis/metabolism

enhanced exercise endurance ( J:197753 )

• fatigue resistance to forced running prior to development of muscular hypertrophy

• fatigue resistance in isolated soleus muscles stimulated in a tissue bath

cellular

increased apoptosis ( J:197753 )

• in alveolar septal cells