Phenotypes associated with this allele

• Allele Symbol: Clec4g^tm1.1Fhe
• Allele Name: targeted mutation 1.1, Fuchu He
• Allele ID: MGI:5510586
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4g^tm1.1Fhe/Clec4g^tm1.1Fhe	B6.129-Clec4g^tm1.1Fhe	MGI:5510710

Genotype
MGI:5510710

hm1

• Allelic Composition: Clec4g^tm1.1Fhe/Clec4g^tm1.1Fhe
• Genetic Background: B6.129-Clec4g^tm1.1Fhe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:200968 )

N • normal numbers and ratios of CD4+, CD8+, and double positive T cells in the thymus

N • normal T cell populations in the spleen and lymph nodes

abnormal immune system cell morphology ( J:200968 )

increased CD4-positive, alpha-beta T cell number ( J:200968 )

• increased cell numbers in the liver

• CD4+ cells from Tg(DO11.10)10Dlo donors found in the liver in significantly greater numbers than in livers of control recipients

increased CD8-positive, alpha-beta T cell number ( J:194891 , J:200968 )

• increased numbers of activated CD8+ T cells in the liver 7 days after adenovirus infection (J:194891)

• increased cell number in the liver (J:200968)

increased activated T cell number ( J:200968 )

abnormal immune system physiology ( J:200968 )

liver inflammation ( J:200968 )

• exacerbated liver injury in Con A treated mice

• greater histologic liver damage

• more lymphocytes in the liver with elevated TNF alpha and IFN gamma

decreased susceptibility to Adenoviridae infection ( J:194891 )

• more rapid clearance of adenovirus

• increased numbers of activated CD8+ T cells in the liver 7 days after adenovirus infection

• hepatitis B antigens are cleared more rapidly from serum

• fewer infected hepatocytes 14 days after hepatitis B virus infection

liver/biliary system

liver inflammation ( J:200968 )

• exacerbated liver injury in Con A treated mice

• greater histologic liver damage

• more lymphocytes in the liver with elevated TNF alpha and IFN gamma

homeostasis/metabolism

increased circulating alanine transaminase level ( J:200968 )

increased circulating aspartate transaminase level ( J:200968 )

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:200968 )

• increased cell numbers in the liver

• CD4+ cells from Tg(DO11.10)10Dlo donors found in the liver in significantly greater numbers than in livers of control recipients

increased CD8-positive, alpha-beta T cell number ( J:194891 , J:200968 )

• increased numbers of activated CD8+ T cells in the liver 7 days after adenovirus infection (J:194891)

• increased cell number in the liver (J:200968)

increased activated T cell number ( J:200968 )