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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctdnep1tm1Ryn
targeted mutation 1, Ryuichi Nishinakamura
MGI:5510826
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctdnep1tm1Ryn/Ctdnep1tm1Ryn involves: 129P2/OlaHsd * C57BL/6 MGI:5510849
cx2
 		Bmp4tm1Blh/Bmp4+
Ctdnep1tm1Ryn/Ctdnep1tm1Ryn 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:5510851
cx3
 		Ctdnep1tm1Ryn/Ctdnep1+
Wnt3tm1Brd/Wnt3+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5510852


Genotype
MGI:5510849
hm1
Allelic
Composition		 Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1tm1Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Arrested development and abnormal morphogenesis of extraembryonic tissues in Ctdnep1tm1Ryn/Ctdnep1tm1Ryn embryos

mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:199855 )
• no viable mice are recovered at E11.5
embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:199855 )
• despite being present in Mendelian ratios at E7.5, only a few poorly developed mice are recovered at E9.5

reproductive system
abnormal primordial germ cell morphology ( J:199855 )
• AP+ cells fail to transit from mesoderm to the endoderm

embryo
abnormal embryonic tissue morphology ( J:199855 )
• poorly developed head fold and trunk at E8.25
abnormal head fold morphology ( J:199855 )
• poorly developed at E8.25
abnormal parietal endoderm morphology ( J:199855 )
• ruffling of the yolk sac endoderm on the posterior side at E7.5 to E7.75
• pleated yolk sac endoderm at E8.25

cellular
abnormal primordial germ cell morphology ( J:199855 )
• AP+ cells fail to transit from mesoderm to the endoderm




Genotype
MGI:5510851
cx2
Allelic
Composition		 Bmp4tm1Blh/Bmp4+
Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (23 available)
Ctdnep1tm1Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial germ cell number ( J:199855 )
• severely reduced as in Ctdnep1tm1Ryn homozygotes

cellular
decreased primordial germ cell number ( J:199855 )
• severely reduced as in Ctdnep1tm1Ryn homozygotes




Genotype
MGI:5510852
cx3
Allelic
Composition		 Ctdnep1tm1Ryn/Ctdnep1+
Wnt3tm1Brd/Wnt3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctdnep1tm1Ryn mutation (0 available); any Ctdnep1 mutation (20 available)
Wnt3tm1Brd mutation (0 available); any Wnt3 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decrease in the number of Dppa3+ primordial germ cells in Ctdnep1tm1Ryn/Ctdnep1+ Wnt3tm1Brd/Wnt3+ embryos

cellular
decreased primordial germ cell number ( J:199855 )
• half as many Dppa3+ primordial germ cells as in wild-type mice

reproductive system
decreased primordial germ cell number ( J:199855 )
• half as many Dppa3+ primordial germ cells as in wild-type mice

embryo
embryo phenotype ( J:199855 )
N
• mice do not exhibit morphological defects




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory