Phenotypes associated with this allele

• Allele Symbol: Ctdnep1^tm2Ryn
• Allele Name: targeted mutation 2, Ryuichi Nishinakamura
• Allele ID: MGI:5510831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctdnep1^tm2Ryn/Ctdnep1^tm2Ryn	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5510850

Genotype
MGI:5510850

hm1

• Allelic Composition: Ctdnep1^tm2Ryn/Ctdnep1^tm2Ryn
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199855 )

• no viable mice are recovered at E11.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:199855 )

• despite being present in Mendelian ratios at E7.5, only a few poorly developed mice are recovered at E9.5

reproductive system

abnormal primordial germ cell morphology ( J:199855 )

• AP+ cells fail to transit from mesoderm to the endoderm

decreased primordial germ cell number ( J:199855 )

• severely reduced

embryo

abnormal embryonic tissue morphology ( J:199855 )

• poorly developed head fold and trunk at E8.25

abnormal head fold morphology ( J:199855 )

• poorly developed at E8.25

absent allantois ( J:199855 )

absent amnion ( J:199855 )

abnormal extraembryonic coelom morphology ( J:199855 )

• diminutive

abnormal parietal endoderm morphology ( J:199855 )

• ruffling of the yolk sac endoderm on the posterior side at E7.5 to E7.75

• pleated yolk sac endoderm at E8.25

abnormal extraembryonic mesoderm development ( J:199855 )

• clumping at E8.25

cellular

abnormal primordial germ cell morphology ( J:199855 )

• AP+ cells fail to transit from mesoderm to the endoderm

decreased primordial germ cell number ( J:199855 )

• severely reduced