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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4rtm2.2Stmr
targeted mutation 2.2, Stephen M Strittmatter
MGI:5510952
Summary 2 genotypes


Genotype
MGI:5510954
hm1
Allelic
Composition		 Rtn4rtm2.2Stmr/Rtn4rtm2.2Stmr
Genetic
Background		 B6.Cg-Rtn4rtm2.2Stmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm2.2Stmr mutation (0 available); any Rtn4r mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system regeneration ( J:201118 )
• stronger axonal regeneration after optic nerve crush without zymosan injection or lens injury compared with wild-type mice




Genotype
MGI:5510953
cn2
Allelic
Composition		 Rtn4rtm2.1Stmr/Rtn4rtm2.2Stmr
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 B6.Cg-Rtn4rtm2.1Stmr/Rtn4rtm2.2Stmr Tg(CAG-cre/Esr1*)5Amc0
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4rtm2.1Stmr mutation (0 available); any Rtn4r mutation (24 available)
Rtn4rtm2.2Stmr mutation (0 available); any Rtn4r mutation (24 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system regeneration ( J:201118 )
• after optic nerve crush, tamoxifen-treated mice exhibit stronger axonal regeneration compared with control mice though not as complete as in constitutive knock-out mice
• after spinal cord dorsal hemisection injury, tamoxifen-treated mice exhibit improvement of motor function and 5HT fiber density compared with control mice
• however, untreated mice exhibit normal regeneration




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory