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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox11tm1.1Llei
targeted mutation 1.1, Lei Lei
MGI:5510957
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox11tm1.1Llei/Sox11tm1.1Llei involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5510978
cn2
 		Sox11tm1.1Llei/Sox11tm1.1Llei
Tg(Nes-cre/ERT2)73Lfp/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5510981


Genotype
MGI:5510978
hm1
Allelic
Composition		 Sox11tm1.1Llei/Sox11tm1.1Llei
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Llei mutation (1 available); any Sox11 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198233 )
• mice are healthy and fertile




Genotype
MGI:5510981
cn2
Allelic
Composition		 Sox11tm1.1Llei/Sox11tm1.1Llei
Tg(Nes-cre/ERT2)73Lfp/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Llei mutation (1 available); any Sox11 mutation (15 available)
Tg(Nes-cre/ERT2)73Lfp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:198233 )
• reduced hippocampal neurogenesis in tamoxifen-treated mice
abnormal neuronal precursor proliferation ( J:198233 )
• tamoxifen-treated mice exhibit reduced neuronal precursor proliferation in the subgranular zone compared with control mice

cellular
abnormal neuron differentiation ( J:198233 )
• reduced hippocampal neurogenesis in tamoxifen-treated mice
abnormal neuronal precursor proliferation ( J:198233 )
• tamoxifen-treated mice exhibit reduced neuronal precursor proliferation in the subgranular zone compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory