Phenotypes associated with this allele

• Allele Symbol: Igsf21^{tm2a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5511724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igsf21^tm2a(EUCOMM)Hmgu/Igsf21^tm2a(EUCOMM)Hmgu	B6J;B6N-Igsf21^tm2a(EUCOMM)Hmgu	MGI:6119537

Genotype
MGI:6119537

hm1

• Allelic Composition: Igsf21^{tm2a(EUCOMM)Hmgu}/Igsf21^{tm2a(EUCOMM)Hmgu}
• Genetic Background: B6J;B6N-Igsf21^{tm2a(EUCOMM)Hmgu}
• Cell Lines: HEPD0796_5_F07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:249826 )

N • mice exhibit no brain abnormalities including a normal hippocampus, symmetric and asymmetric synapse numbers, and mEPSC frequency and amplitude

abnormal synaptic vesicle number ( J:249826 )

• reduced total and docked synaptic vesicles in presynaptic boutons of symmetric synapses in the stratum radiatum

• slight decrease in the number of docked synaptic vesicles in the presynaptic boutons of asymmetric synapses in the perisomatic regions in the stratum pyramidale

• however, mice exhibit normal numbers of total and docked synaptic vesicles in presynaptic boutons of asymmetric synapses in the stratum radiatum and total synaptic vesicles in the presynaptic boutons of asymmetric synapses in the perisomatic regions in the stratum pyramidale

decreased miniature inhibitory postsynaptic current frequency ( J:249826 )

• decreased mIPSC frequency, but not amplitude

decreased prepulse inhibition ( J:249826 )

• of the acoustic startle reflex

behavior/neurological

behavior/neurological phenotype ( J:249826 )

N • mice exhibit normal motor activity and coordination