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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cmtm7tm2a(EUCOMM)Hmgu
targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH
MGI:5511805
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+ involves: C57BL/6 * C57BL/6N MGI:6100916
cx2
Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+
Rag1tm1Fwa/Rag1tm1Fwa
chimera involves: C57BL/6 * C57BL/6N MGI:6100917


Genotype
MGI:6100916
ht1
Allelic
Composition
Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+
Genetic
Background
involves: C57BL/6 * C57BL/6N
Cell Lines HEPD0787_6_G03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm7tm2a(EUCOMM)Hmgu mutation (0 available); any Cmtm7 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• heterozygotes die shortly after birth, suggesting haploinsufficiency




Genotype
MGI:6100917
cx2
Allelic
Composition
Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+
Rag1tm1Fwa/Rag1tm1Fwa
Genetic
Background
chimera involves: C57BL/6 * C57BL/6N
Cell Lines HEPD0787_6_G03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmtm7tm2a(EUCOMM)Hmgu mutation (0 available); any Cmtm7 mutation (29 available)
Rag1tm1Fwa mutation (0 available); any Rag1 mutation (123 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• greatly reduced frequency of IgM-secreting plasma cells
• B-1a cells expressed significantly lower levels of BCR
• B-1a cell population was dramatically reduced in the peritoneal caivty
• impaired survival of B-1a cells
• B-1a and B-1b cells show reduced proliferation

immune system
• greatly reduced frequency of IgM-secreting plasma cells
• B-1a cells expressed significantly lower levels of BCR
• B-1a cell population was dramatically reduced in the peritoneal caivty
• impaired survival of B-1a cells
• B-1a and B-1b cells show reduced proliferation

cellular
• B-1a and B-1b cells show reduced proliferation





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory