mortality/aging
• heterozygotes die shortly after birth, suggesting haploinsufficiency
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Allele Symbol Allele Name Allele ID |
Cmtm7tm2a(EUCOMM)Hmgu targeted mutation 2a, Helmholtz Zentrum Muenchen GmbH MGI:5511805 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• heterozygotes die shortly after birth, suggesting haploinsufficiency
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• greatly reduced frequency of IgM-secreting plasma cells
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• B-1a cells expressed significantly lower levels of BCR
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• B-1a cell population was dramatically reduced in the peritoneal caivty
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• impaired survival of B-1a cells
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• B-1a and B-1b cells show reduced proliferation
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• greatly reduced frequency of IgM-secreting plasma cells
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• B-1a cells expressed significantly lower levels of BCR
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• B-1a cell population was dramatically reduced in the peritoneal caivty
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• impaired survival of B-1a cells
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• B-1a and B-1b cells show reduced proliferation
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• B-1a and B-1b cells show reduced proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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