Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}
• Allele Name: targeted mutation 3, TaconicArtemis
• Allele ID: MGI:5512655
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm3(tetO-Mir193)Arte/Gt(ROSA)26Sor^tm3(tetO-Mir193)Arte	involves: 129 * BALB/c * C57BL/6	MGI:5512667
ht2	Gt(ROSA)26Sor^tm3(tetO-Mir193)Arte/Gt(ROSA)26Sor^+	involves: 129 * BALB/c * C57BL/6	MGI:5512665

Genotype
MGI:5512667

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}/Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:197989 )

• after 6 weeks in doxycycline-treated mice

renal/urinary system

albuminuria ( J:197989 )

• in doxycycline-treated mice

abnormal kidney morphology ( J:197989 )

• contracted kidneys with tubular atrophy, scarring, cyst formation and focal tubular regeneration in dead doxycycline-treated mice

kidney cyst ( J:197989 )

• in dead doxycycline-treated mice

podocyte foot process effacement ( J:197989 )

• from 4 weeks on in doxycycline-treated mice

abnormal podocyte slit diaphragm morphology ( J:197989 )

• fused from 4 weeks on in doxycycline-treated mice

abnormal renal glomerulus morphology ( J:197989 )

• doxycycline-treated mice exhibit progressive glomerular lesions and irregularities that progress to focal sclerosis unlike in control mice

glomerulosclerosis ( J:197989 )

• focal sclerosis in doxycycline-treated mice that is elevated with time

abnormal renal tubule morphology ( J:197989 )

• focal tubular regeneration in dead doxycycline-treated mice

renal tubule atrophy ( J:197989 )

• in dead doxycycline-treated mice

homeostasis/metabolism

albuminuria ( J:197989 )

• in doxycycline-treated mice

growth/size/body

kidney cyst ( J:197989 )

• in dead doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal segmental glomerulosclerosis		DOID:1312	OMIM:PS603278	J:197989

Genotype
MGI:5512665

ht2

• Allelic Composition: Gt(ROSA)26Sor^{tm3(tetO-Mir193)Arte}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6

mortality/aging

premature death ( J:197989 )

• after 12 weeks in doxycycline-treated mice

renal/urinary system

albuminuria ( J:197989 )

• in doxycycline-treated mice

abnormal kidney morphology ( J:197989 )

• contracted kidneys with tubular atrophy, scarring, cyst formation and focal tubular regeneration in dead doxycycline-treated mice

kidney cyst ( J:197989 )

• in dead doxycycline-treated mice

podocyte foot process effacement ( J:197989 )

• from 4 weeks on in doxycycline-treated mice

abnormal podocyte slit diaphragm morphology ( J:197989 )

• fused from 4 weeks on in doxycycline-treated mice

abnormal renal glomerulus morphology ( J:197989 )

• doxycycline-treated mice exhibit progressive glomerular lesions and irregularities that progress to focal sclerosis unlike in control mice

glomerulosclerosis ( J:197989 )

• focal sclerosis in doxycycline-treated mice that is elevated with time

abnormal renal tubule morphology ( J:197989 )

• focal tubular regeneration in dead doxycycline-treated mice

renal tubule atrophy ( J:197989 )

• in dead doxycycline-treated mice

homeostasis/metabolism

albuminuria ( J:197989 )

• in doxycycline-treated mice

growth/size/body

kidney cyst ( J:197989 )

• in dead doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal segmental glomerulosclerosis		DOID:1312	OMIM:PS603278	J:197989