All Phenotypes Braf<tm2.1Urr> MGI Mouse

premature death ( J:199842 )

• no mice survive beyond P28

postnatal lethality, incomplete penetrance ( J:199842 )

• mice begin to die around P17

impaired neuron differentiation ( J:199842 )

• in the dentate granule cell layer

• however, no increase in astrocytic differentiation is observed in the dentate gyrus

increased neuronal precursor proliferation ( J:199842 )

• expansion of the pool of proliferating hippocampal progenitor cells in the third postnatal week

decreased brain weight ( J:199842 )

• at P10 and P20

abnormal hippocampus granule cell layer ( J:199842 )

• reduced volume of the dentate granule cell layer

• reduced volume at P21 but not P12

abnormal cerebellum morphology ( J:199842 )

• cytoarchitectonic alterations affecting all lobes at P21

abnormal Purkinje cell morphology ( J:199842 )

• irregular positions in the flocculonodular lobe LX

• Purkinje cells appear elongated

abnormal Purkinje cell dendrite morphology ( J:199842 )

• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length

decreased Purkinje cell number ( J:199842 )

• in the flocculonodular lobe LX

abnormal cerebellar molecular layer ( J:199842 )

• reduced and irregular arborization in the cerebellar molecular layer with more than 2 times lengthening of primary dendrite length

abnormal cerebellum vermis lobule morphology ( J:199842 )

• reduced glomeruli size indicating that the synapses of the granule cells with mossy fiber and Golgi cells do not form correctly

abnormal cerebellum vermis lobule I morphology ( J:199842 )

• reduced length with less well demarcated and fuzzy border

abnormal cerebellum vermis lobule II morphology ( J:199842 )

• reduced length with less well demarcated and fuzzy border

abnormal cerebellum vermis lobule III morphology ( J:199842 )

• reduced length

abnormal cerebellum vermis lobule V morphology ( J:199842 )

• reduced length

abnormal cerebellum vermis lobule VII morphology ( J:199842 )

• less well demarcated and fuzzy border

abnormal cerebellum vermis lobule X morphology ( J:199842 )

• ced length with less well demarcated and fuzzy border and disorganized glomeruli

cerebellum hypoplasia ( J:199842 )

• at P21

increased aggression ( J:199842 )

• autoaggression (biting of their toes) in 13 of 15 mice

impaired balance ( J:199842 )

• impaired ability to walk and balance on a rod

• however, mice walk normally otherwise

impaired coordination ( J:199842 )