Phenotypes associated with this allele

• Allele Symbol: Mpig6b^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5512767
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpig6b^tm1.1Arte/Mpig6b^tm1.1Arte	involves: C57BL/6NTac	MGI:5512896
cx2	Mpig6b^tm1.1Arte/Mpig6b^tm1.1Arte Gp6^tm1Ware/Gp6^tm1Ware	involves: C57BL/6 * C57BL/6NTac	MGI:5512897

Genotype
MGI:5512896

hm1

• Allelic Composition: Mpig6b^tm1.1Arte/Mpig6b^tm1.1Arte
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet ATP level ( J:201266 )

• failure to secrete ATP in response to high concentrations of collagen-related peptide or convulxin

abnormal megakaryocyte differentiation ( J:201266 )

• abnormal megakaryocyte function and proplatelet formation

enlarged spleen ( J:201266 )

• moderately

extramedullary hematopoiesis ( J:201266 )

increased megakaryocyte cell number ( J:201266 )

• clusters of megakaryocytes in the bone marrow and red pulp

thrombocytopenia ( J:201266 )

• macrothrombocytopenia

increased mean platelet volume ( J:201266 )

abnormal spleen red pulp morphology ( J:201266 )

• clusters of megakaryocytes in the bone marrow and red pulp

spleen fibrosis ( J:201266 )

abnormal platelet physiology ( J:201266 )

• increased platelet turnover

• poor adhesion and aggregation

decreased platelet aggregation ( J:201266 )

skeleton

abnormal bone marrow morphology ( J:201266 )

• clusters of megakaryocytes in the bone marrow and red pulp

myelofibrosis ( J:201266 )

homeostasis/metabolism

decreased platelet ATP level ( J:201266 )

• failure to secrete ATP in response to high concentrations of collagen-related peptide or convulxin

abnormal platelet physiology ( J:201266 )

• increased platelet turnover

• poor adhesion and aggregation

decreased platelet aggregation ( J:201266 )

increased bleeding time ( J:201266 )

cellular

decreased platelet ATP level ( J:201266 )

• failure to secrete ATP in response to high concentrations of collagen-related peptide or convulxin

abnormal megakaryocyte differentiation ( J:201266 )

• abnormal megakaryocyte function and proplatelet formation

immune system

enlarged spleen ( J:201266 )

• moderately

abnormal spleen red pulp morphology ( J:201266 )

• clusters of megakaryocytes in the bone marrow and red pulp

spleen fibrosis ( J:201266 )

growth/size/body

enlarged spleen ( J:201266 )

• moderately

Genotype
MGI:5512897

cx2

• Allelic Composition: Mpig6b^tm1.1Arte/Mpig6b^tm1.1Arte; Gp6^tm1Ware/Gp6^tm1Ware
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

hematopoietic system

thrombocytopenia ( J:201266 )

• not as severe as in AU023871^tm1.1Arte homozygotes