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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ostm1om
omi
MGI:5512861
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ostm1om/Ostm1om C3HeB/FeJ-Ostm1om MGI:5514055
ht2
 		Ostm1gl/Ostm1om involves: C3HeB/FeJ MGI:5514054


Genotype
MGI:5514055
hm1
Allelic
Composition		 Ostm1om/Ostm1om
Genetic
Background		 C3HeB/FeJ-Ostm1om
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ostm1om mutation (1 available); any Ostm1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, incomplete penetrance ( J:195249 )
• however, provision with soft food improves survival
premature death ( J:195249 )
• shortened life span in some mice

skeleton
abnormal incisor morphology ( J:195249 )
• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors
• most incisors erupt but appear damaged and degenerate within the first month of life
abnormal molar morphology ( J:195249 )
• molars are not regularly aligned
• upper molar 3 appears damaged
• some molars are still covered with bone and an epithelial cell layer
failure of tooth eruption ( J:195249 )
• most molars fail to erupt
abnormal maxilla morphology ( J:195249 )
• rough appearance around the roots of damaged upper incisors
• sclerosis in the maxillary area
abnormal maxillary zygomatic process morphology ( J:195249 )
• the zygomatic process of the maxilla is thicker and continues to be thick halfway into the zygomatic bone compared to in wild-type mice
abnormal long bone morphology ( J:195249 )
• layered appearance
abnormal deltoid tuberosity morphology ( J:195249 )
• increased density and abnormal morphology
abnormal femur morphology ( J:195249 )
• increased density of the diaphyses in female mice
• increased density at the distal epiphysis
abnormal rib morphology ( J:195249 )
• thick proximal ribs 1 through 8, especially on the dorsal parts
decreased bone mineral density ( J:195249 )
• full body, femur or right knee in female mice at 8 and 12 weeks
• in male mice at 8 but not 12 weeks
abnormal compact bone morphology ( J:195249 )
• in the jaw, the compact bone is invaded by blood vessels and has a very irregular structure
abnormal trabecular bone morphology ( J:195249 )
• disorganized in the jaw
osteopetrosis ( J:195249 )
• progressive in female, but not male, mice

craniofacial
abnormal incisor morphology ( J:195249 )
• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors
• most incisors erupt but appear damaged and degenerate within the first month of life
abnormal molar morphology ( J:195249 )
• molars are not regularly aligned
• upper molar 3 appears damaged
• some molars are still covered with bone and an epithelial cell layer
failure of tooth eruption ( J:195249 )
• most molars fail to erupt
abnormal maxilla morphology ( J:195249 )
• rough appearance around the roots of damaged upper incisors
• sclerosis in the maxillary area
abnormal maxillary zygomatic process morphology ( J:195249 )
• the zygomatic process of the maxilla is thicker and continues to be thick halfway into the zygomatic bone compared to in wild-type mice

homeostasis/metabolism
decreased circulating LDL cholesterol level ( J:195249 )
• likely due to poor nutritional status
decreased circulating triglyceride level ( J:195249 )
• likely due to poor nutritional status

growth/size/body
abnormal incisor morphology ( J:195249 )
• at P14, P21 and P30 to P32, some mice exhibit small or thinner teeth or missing incisors
• most incisors erupt but appear damaged and degenerate within the first month of life
short incisors ( J:195249 )
abnormal molar morphology ( J:195249 )
• molars are not regularly aligned
• upper molar 3 appears damaged
• some molars are still covered with bone and an epithelial cell layer
failure of tooth eruption ( J:195249 )
• most molars fail to erupt
decreased lean body mass ( J:195249 )
decreased body size ( J:195249 )
• around time of weaning

adipose tissue

pigmentation
abnormal coat/hair pigmentation ( J:195249 )
• more grey less yellow coat color

hematopoietic system
decreased hemoglobin content ( J:195249 )
• likely due to poor nutritional status

integument
abnormal coat/hair pigmentation ( J:195249 )
• more grey less yellow coat color

limbs/digits/tail
abnormal deltoid tuberosity morphology ( J:195249 )
• increased density and abnormal morphology
abnormal femur morphology ( J:195249 )
• increased density of the diaphyses in female mice
• increased density at the distal epiphysis




Genotype
MGI:5514054
ht2
Allelic
Composition		 Ostm1gl/Ostm1om
Genetic
Background		 involves: C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ostm1gl mutation (1 available); any Ostm1 mutation (23 available)
Ostm1om mutation (1 available); any Ostm1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:195249 )
• however, mice are viable on a soft food diet

craniofacial
absent incisors ( J:195249 )
• at P21

pigmentation
abnormal coat/hair pigmentation ( J:195249 )
• grey appearance at P21

integument
abnormal coat/hair pigmentation ( J:195249 )
• grey appearance at P21

growth/size/body
absent incisors ( J:195249 )
• at P21

skeleton
absent incisors ( J:195249 )
• at P21




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory