Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Lyn*)#Paau
• Allele Name: transgene insertion, Patrick Auberger
• Allele ID: MGI:5512882
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-Lyn*)#Paau/0 Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:5512885
cx2	Rag1^tm1Mom/Rag1^tm1Mom Tg(CAG-Lyn*)#Paau/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:5512886
tg3	Tg(CAG-Lyn*)#Paau/0	B6.Cg-Tg(CAG-Lyn*)#Paau	MGI:5512884

Genotype
MGI:5512885

cx1

• Allelic Composition: Tg(CAG-Lyn*)#Paau/0; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:151886 )

N • mice exhibit normal skin architecture and all mice reach adulthood

Genotype
MGI:5512886

cx2

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tg(CAG-Lyn*)#Paau/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

immune system

decreased inflammatory response ( J:151886 )

• skin inflammatory disease is improved compared to single Tg(CAG-Lyn*)#Paau transgenic mice

Genotype
MGI:5512884

tg3

• Allelic Composition: Tg(CAG-Lyn*)#Paau/0
• Genetic Background: B6.Cg-Tg(CAG-Lyn*)#Paau

mortality/aging

postnatal lethality, incomplete penetrance ( J:151886 )

• majority of mice with the acute skin phenotype die within 2 weeks

integument

increased keratinocyte proliferation ( J:151886 )

epidermal spongiosis ( J:151886 )

skin inflammation ( J:151886 )

• skin shows inflammatory infiltrates into the epidermis and dermis, including the presence of CD4+ T cells and an increased number of granulocytes and macrophages

• skin hyperproliferation is accompanied by a hematopoietic cell infiltration

hyperkeratosis ( J:151886 )

parakeratosis ( J:151886 )

thin epidermis stratum granulosum ( J:151886 )

• hypogranulosis

acanthosis ( J:151886 )

reddish skin ( J:151886 )

scaly skin ( J:151886 )

skin lesions ( J:151886 )

• treatment with etanercept improves skin lesions

psoriasis ( J:151886 )

• mutants develop skin defects resembling psoriasis after P6

• mutants either develop a mild skin phenotype characterized by small scaly patches affecting the ears, tails, paws and hairy back skin or an acute skin phenotype characterized by skin lesions covering the entire body and death within 2 weeks

• the skin defect phenotype is seen as early as 3 days after birth, is most severe at 2 weeks of age and a reversion is seen in surviving mice by 4 weeks

thick skin ( J:151886 )

• inflexible thickened skin

growth/size/body

decreased body size ( J:151886 )

• mice with the acute skin phenotype are runted

behavior/neurological

decreased food intake ( J:151886 )

• mice with the acute skin phenotype exhibit decreased feeding activity

cellular

increased keratinocyte proliferation ( J:151886 )

homeostasis/metabolism

extremity edema ( J:151886 )

• some mutants exhibit edema of paws with alteration of nails

epidermal spongiosis ( J:151886 )

immune system

skin inflammation ( J:151886 )

• skin shows inflammatory infiltrates into the epidermis and dermis, including the presence of CD4+ T cells and an increased number of granulocytes and macrophages

• skin hyperproliferation is accompanied by a hematopoietic cell infiltration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:151886