Analysis Tools
neoplasm
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• with 2 low doses of tamoxifen given at 6 weeks, most mice display obvious pituitary tumors between 3 and 5 months upon necropsy; pituitaries of remaining animals contained small tumors in the anterior lobe upon histological analysis
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endocrine/exocrine glands
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• at E15.5, embryos show an enlarged anterior pituitary, with foci of accumulation of beta-catenin when tamoxifen induction is done at E10.5; clusters are observed to contain undifferentiated cells that do not express proliferation marker Ki67
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• with 2 low doses of tamoxifen given at 6 weeks, most mice display obvious pituitary tumors between 3 and 5 months upon necropsy; pituitaries of remaining animals contained small tumors in the anterior lobe upon histological analysis
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nervous system
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• at E15.5, embryos show an enlarged anterior pituitary, with foci of accumulation of beta-catenin when tamoxifen induction is done at E10.5; clusters are observed to contain undifferentiated cells that do not express proliferation marker Ki67
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• with 2 low doses of tamoxifen given at 6 weeks, most mice display obvious pituitary tumors between 3 and 5 months upon necropsy; pituitaries of remaining animals contained small tumors in the anterior lobe upon histological analysis
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