Phenotypes associated with this allele

• Allele Symbol: Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}
• Allele Name: targeted mutation 2.1, Xin Zhang
• Allele ID: MGI:5512912
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^tm2.1(Pax6_i5a,Pax2)Xzh/Pax6^tm2.1(Pax6_i5a,Pax2)Xzh	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5512979
ht2	Pax6^tm2.1(Pax6_i5a,Pax2)Xzh/Pax6^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5512978

Genotype
MGI:5512979

hm1

• Allelic Composition: Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}/Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

No eye structure is seen in E15.5 homozygous Pax6^{tm2(Pax6_i5a,Pax2)Xzh} or Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh} mutants

vision/eye

abnormal eye development ( J:198381 )

• no eye structure at E15.5

• failure of lends induction at E15.5

abnormal retina development ( J:198381 )

• disrupted retinal development with no patterning of optic vesicle into retinal pigmented epithelium, optic disc and neural retina

nervous system

abnormal neuronal precursor proliferation ( J:198381 )

• increased cell proliferation in the subventricular zone at E14.5 that is not as severe as in Pax6^Sey-Neu homozygotes

abnormal telencephalon development ( J:198381 )

• telecephalon patterning rescue is stronger than in Pax6^{tm2(Pax6_i5a,Pax2)Xzh} homozygotes

abnormal cortical plate morphology ( J:198381 )

• increased cortical thickness compared with Pax6^Sey-Neu homozygotes

cellular

abnormal neuronal precursor proliferation ( J:198381 )

• increased cell proliferation in the subventricular zone at E14.5 that is not as severe as in Pax6^Sey-Neu homozygotes

Genotype
MGI:5512978

ht2

• Allelic Composition: Pax6^{tm2.1(Pax6_i5a,Pax2)Xzh}/Pax6⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

vision/eye

corneal-lenticular stalk ( J:198381 )