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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Maged1tm1Xgao
targeted mutation 1, Xiang Gao
MGI:5512987
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Maged1tm1Xgao/Maged1tm1Xgao B6.Cg-Maged1tm1Xgao MGI:5512993
ht2
 		Maged1tm1Xgao/Maged1+ B6.Cg-Maged1tm1Xgao MGI:5512994
ot3
 		Maged1tm1Xgao/Y B6.Cg-Maged1tm1Xgao MGI:5512992


Genotype
MGI:5512993
hm1
Allelic
Composition		 Maged1tm1Xgao/Maged1tm1Xgao
Genetic
Background		 B6.Cg-Maged1tm1Xgao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1tm1Xgao mutation (0 available); any Maged1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior ( J:200375 )
• the number of rest bouts is slightly increased in the light phase compared with wild-type mice
• the average rest bout duration is decreased in both the light and dark phase compared with wild-type mice
shortened circadian behavior period ( J:200375 )
• of locomotor activities
abnormal circardian behavior entrainment ( J:200375 )
• after a 4 hour advance shift of the LD cycle, mice exhibit immediate advance and re-entrainment within 3 to 4 days unlike wild-type mice that take 6 to 7 days to re-entrain




Genotype
MGI:5512994
ht2
Allelic
Composition		 Maged1tm1Xgao/Maged1+
Genetic
Background		 B6.Cg-Maged1tm1Xgao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1tm1Xgao mutation (0 available); any Maged1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
shortened circadian behavior period ( J:200375 )
• of locomotor activities that is not as much as in homozygotes




Genotype
MGI:5512992
ot3
Allelic
Composition		 Maged1tm1Xgao/Y
Genetic
Background		 B6.Cg-Maged1tm1Xgao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1tm1Xgao mutation (0 available); any Maged1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior ( J:200375 )
• the number of rest bouts is slightly increased in the light phase compared with wild-type mice
• the average rest bout duration is decreased in both the light and dark phase compared with wild-type mice
shortened circadian behavior period ( J:200375 )
• of locomotor activities
abnormal circardian behavior entrainment ( J:200375 )
• after a 4 hour advance shift of the LD cycle, mice exhibit immediate advance and re-entrainment within 3 to 4 days unlike wild-type mice that take 6 to 7 days to re-entrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory