Phenotypes associated with this allele

• Allele Symbol: Cnih2^tm1.1Ran
• Allele Name: targeted mutation 1.1, Roger A Nicoll
• Allele ID: MGI:5513017
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513845
cn2	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513846
cn3	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Neurod6^tm1(cre)Kan/Neurod6^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac	MGI:5513847
cn4	Cnih2^tm1.1Ran/Cnih2^tm1.1Ran Cnih3^tm1.1Ran/Cnih3^tm1.1Ran	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5513850

Genotype
MGI:5513845

hm1

• Allelic Composition: Cnih2^tm1.1Ran/Cnih2^tm1.1Ran
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:197912 )

• mice are indistinguishable from wild-type mice

Genotype
MGI:5513846

cn2

• Allelic Composition: Cnih2^tm1.1Ran/Cnih2^tm1.1Ran
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

nervous system

nervous system phenotype ( J:197912 )

N • NMDAR-evoked excitatory postsynaptic current amplitude and paired-pulse ratio are normal

abnormal AMPA-mediated synaptic currents ( J:197912 )

• AMPAR deactivation and desensitization in cre-treated neurons are faster than in control mice

reduced AMPA-mediated synaptic currents ( J:197912 )

• reduced AMPAR-evoked excitatory postsynaptic current amplitude with speedier decay in acute mouse slices infected with a cre-expressing adenovirus or slices transfected with cre

• reduced AMPAR somatic extrasynaptic currents in cre-treated neurons

abnormal miniature excitatory postsynaptic currents ( J:197912 )

• reduced amplitude with faster decay in cre-infected neurons

Genotype
MGI:5513847

cn3

• Allelic Composition: Cnih2^tm1.1Ran/Cnih2^tm1.1Ran; Neurod6^tm1(cre)Kan/Neurod6⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6NTac

nervous system

nervous system phenotype ( J:197912 )

N • NMDAR-evoked excitatory postsynaptic current amplitude

reduced AMPA-mediated synaptic currents ( J:197912 )

• in CA1 pyramidal neurons, dentate gyrus, and layer 2/3 pyramidal neurons in the barrel cortex

Genotype
MGI:5513850

cn4

• Allelic Composition: Cnih2^tm1.1Ran/Cnih2^tm1.1Ran; Cnih3^tm1.1Ran/Cnih3^tm1.1Ran
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

nervous system

nervous system phenotype ( J:197912 )

N • cre-treated neurons exhibit normal AMPAR sensitization and cyclothiazide potentiation of kainate-induced currents

reduced AMPA-mediated synaptic currents ( J:197912 )

• reduced AMPAR-evoked excitatory postsynaptic current in cre-treated neurons to a greater extent than in activated Cnih2^tm1.1Ran neurons

reduced long-term potentiation ( J:197912 )

• in cre-treated neurons

abnormal miniature excitatory postsynaptic currents ( J:197912 )

• cre-infected neurons exhibit reduced amplitude as in activated Cnih2^tm1.1Ran neurons with faster decay than in activated Cnih2^tm1.1Ran neurons