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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnih3tm1.1Ran
targeted mutation 1.1, Roger A Nicoll
MGI:5513018
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnih3tm1.1Ran/Cnih3tm1.1Ran involves: 129S6/SvEvTac * C57BL/6NTac MGI:5513848
cn2
 		Cnih3tm1.1Ran/Cnih3tm1.1Ran involves: 129S6/SvEvTac * C57BL/6NTac MGI:5513849
cn3
 		Cnih2tm1.1Ran/Cnih2tm1.1Ran
Cnih3tm1.1Ran/Cnih3tm1.1Ran 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5513850


Genotype
MGI:5513848
hm1
Allelic
Composition		 Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih3tm1.1Ran mutation (1 available); any Cnih3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:197912 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5513849
cn2
Allelic
Composition		 Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih3tm1.1Ran mutation (1 available); any Cnih3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:197912 )
N
• cre-treated neurons exhibit normal AMPAR- and NMDAR-evoked excitatory postsynaptic currents




Genotype
MGI:5513850
cn3
Allelic
Composition		 Cnih2tm1.1Ran/Cnih2tm1.1Ran
Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnih2tm1.1Ran mutation (1 available); any Cnih2 mutation (11 available)
Cnih3tm1.1Ran mutation (1 available); any Cnih3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:197912 )
N
• cre-treated neurons exhibit normal AMPAR sensitization and cyclothiazide potentiation of kainate-induced currents
reduced AMPA-mediated synaptic currents ( J:197912 )
• reduced AMPAR-evoked excitatory postsynaptic current in cre-treated neurons to a greater extent than in activated Cnih2tm1.1Ran neurons
reduced long-term potentiation ( J:197912 )
• in cre-treated neurons
abnormal miniature excitatory postsynaptic currents ( J:197912 )
• cre-infected neurons exhibit reduced amplitude as in activated Cnih2tm1.1Ran neurons with faster decay than in activated Cnih2tm1.1Ran neurons




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory