Phenotypes associated with this allele

• Allele Symbol: Dhfr^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5513765
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhfr^tm1b(EUCOMM)Wtsi/Dhfr^tm1b(EUCOMM)Wtsi	C57BL/6N-Dhfr^tm1b(EUCOMM)Wtsi/Tcp	MGI:5756985
ht2	Dhfr^tm1b(EUCOMM)Wtsi/Dhfr^+	C57BL/6N-Dhfr^tm1b(EUCOMM)Wtsi/Tcp	MGI:6262282

Genotype
MGI:5756985

hm1

• Allelic Composition: Dhfr^{tm1b(EUCOMM)Wtsi}/Dhfr^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Dhfr^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0459_2_H07

Data Sources

IMPC Data for Dhfr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

Genotype
MGI:6262282

ht2

• Allelic Composition: Dhfr^{tm1b(EUCOMM)Wtsi}/Dhfr⁺
• Genetic Background: C57BL/6N-Dhfr^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0459_2_H07

Data Sources

IMPC Data for Dhfr

hematopoietic system

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - TCP

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - TCP