Phenotypes associated with this allele

• Allele Symbol: Man2b2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5513801
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Man2b2^tm1b(KOMP)Wtsi/Man2b2^tm1b(KOMP)Wtsi	C57BL/6N-Man2b2^tm1b(KOMP)Wtsi/Tcp	MGI:5757332
hm2	Man2b2^tm1b(KOMP)Wtsi/Man2b2^tm1b(KOMP)Wtsi	C57BL/6N-Man2b2^tm1b(KOMP)Wtsi/Wtsi	MGI:6461418

Genotype
MGI:5757332

hm1

• Allelic Composition: Man2b2^{tm1b(KOMP)Wtsi}/Man2b2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Man2b2^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0098_4_A08

Data Sources

IMPC Data for Man2b2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small adrenal glands ( J:211773 )

♂

IMPC - TCP

hematopoietic system

increased eosinophil cell number ( J:211773 )

♀

IMPC - TCP

increased neutrophil cell number ( J:211773 )

♂

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

immune system

increased eosinophil cell number ( J:211773 )

♀

IMPC - TCP

increased neutrophil cell number ( J:211773 )

♂

IMPC - TCP

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

♀

IMPC - TCP

reproductive system

abnormal uterus morphology ( J:211773 )

♀

IMPC - TCP

Genotype
MGI:6461418

hm2

• Allelic Composition: Man2b2^{tm1b(KOMP)Wtsi}/Man2b2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Man2b2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0098_4_A08

Data Sources

IMPC Data for Man2b2

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - WTSI

decreased circulating total protein level ( J:211773 )

♂

IMPC - WTSI