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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dio2tm1Acb
targeted mutation 1, Antonio C Bianco
MGI:5513859
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dio2tm1Acb/Dio2tm1Acb
Tg(Cga-cre)3Sac/0
involves: C57BL/6J * SJL MGI:5513867
cn2
Dio2tm1Acb/Dio2tm1Acb
Tg(GFAP-cre)25Mes/0
involves: FVB/N MGI:5513868


Genotype
MGI:5513867
cn1
Allelic
Composition
Dio2tm1Acb/Dio2tm1Acb
Tg(Cga-cre)3Sac/0
Genetic
Background
involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dio2tm1Acb mutation (0 available); any Dio2 mutation (19 available)
Tg(Cga-cre)3Sac mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice treated with T4 exhibit a lower reduction in serum TSH likely due to impaired T4 to T3 conversion compared with control mice
• with elevated free T4 levels

adipose tissue

endocrine/exocrine glands
N
• mice are systematically euthyroid




Genotype
MGI:5513868
cn2
Allelic
Composition
Dio2tm1Acb/Dio2tm1Acb
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dio2tm1Acb mutation (0 available); any Dio2 mutation (19 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton

endocrine/exocrine glands
N
• mice exhibit normal hypothalamic-pituitary-thyroid axis (HPT), HPT sensitivity and thyroid economy





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory