Phenotypes associated with this allele

• Allele Symbol: Mmp1a^tm1Otin
• Allele Name: targeted mutation 1, Carlos Lopez-Otin
• Allele ID: MGI:5514177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp1a^tm1Otin/Mmp1a^tm1Otin	involves: 129P2/OlaHsd * C57BL/6J	MGI:5514182

Genotype
MGI:5514182

hm1

• Allelic Composition: Mmp1a^tm1Otin/Mmp1a^tm1Otin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotypic features of urethane-induced tumors in Mmp1a^tm1Otin/Mmp1a^tm1Otin mice

immune system

increased interferon-gamma secretion ( J:198586 )

• in the lungs of urethane-treated mice

abnormal interleukin secretion ( J:198586 )

• increased IL1A, IL2, IL17, and IL27 secretion in the lungs of urethane-treated mice

increased interleukin-1 alpha secretion ( J:198586 )

• in the lungs of urethane-treated mice

increased interleukin-17 secretion ( J:198586 )

• in the lungs of urethane-treated mice

increased interleukin-2 secretion ( J:198586 )

• in the lungs of urethane-treated mice

decreased inflammatory response ( J:198586 )

• mice treated with urethane exhibit increased inflammatory infiltrate in the lungs compared with wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:198586 )

♂ • male, but not female, mice treated with urethane develop fewer tumors compared with wild-type mice

abnormal tumor morphology ( J:198586 )

• mice treated with urethane exhibit increased inflammatory infiltrate in the lungs compared with wild-type mice

decreased tumor growth/size ( J:198586 )

♂ • male mice treated with urethane develop fewer large tumors compared with wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:198586 )

♂ • male, but not female, mice treated with urethane develop fewer tumors compared with wild-type mice