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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfb1tm3.1Flv
targeted mutation 3.1, Richard A Flavell
MGI:5514235
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 * NOD MGI:5514239
cn2
 		Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 		involves: 129 * C57BL/6 * DBA/2 * NOD * SJL MGI:5514237


Genotype
MGI:5514239
cn1
Allelic
Composition		 Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1tm3.1Flv mutation (0 available); any Tgfb1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells

hematopoietic system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells




Genotype
MGI:5514237
cn2
Allelic
Composition		 Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1tm3.1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well
increased susceptibility to autoimmune diabetes ( J:196160 )
• rapidly develop diabetes but with a low incidence
• slow kinetics of disease progression

hematopoietic system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory