About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfb1tm3.1Flv
targeted mutation 3.1, Richard A Flavell
MGI:5514235
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 * NOD MGI:5514239
cn2
 		Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0 		involves: 129 * C57BL/6 * DBA/2 * NOD * SJL MGI:5514237


Genotype
MGI:5514239
cn1
Allelic
Composition		 Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1tm3.1Flv mutation (0 available); any Tgfb1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells

hematopoietic system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells




Genotype
MGI:5514237
cn2
Allelic
Composition		 Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1tm3.1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well
increased susceptibility to autoimmune diabetes ( J:196160 )
• rapidly develop diabetes but with a low incidence
• slow kinetics of disease progression

hematopoietic system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory