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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fetubtm1Wja
targeted mutation 1, Willi Jahnen-Dechent
MGI:5514274
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fetubtm1Wja/Fetubtm1Wja B6.Cg-Fetubtm1Wja MGI:5514277
hm2
 		Fetubtm1Wja/Fetubtm1Wja D2.Cg-Fetubtm1Wja MGI:5514278


Genotype
MGI:5514277
hm1
Allelic
Composition		 Fetubtm1Wja/Fetubtm1Wja
Genetic
Background		 B6.Cg-Fetubtm1Wja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fetubtm1Wja mutation (0 available); any Fetub mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:196435 )
N
• male mice are fertile
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization
female infertility ( J:196435 )
• however, infertility can be rescued by liver-derived Fetuinb
impaired fertilization ( J:196435 )
• no oocytes show signs of fertilization after natural mating
• however, fertilization is restored by laser perforation of the zona pellucida barrier

cellular
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization




Genotype
MGI:5514278
hm2
Allelic
Composition		 Fetubtm1Wja/Fetubtm1Wja
Genetic
Background		 D2.Cg-Fetubtm1Wja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fetubtm1Wja mutation (0 available); any Fetub mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:196435 )
N
• male mice are fertile
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization
female infertility ( J:196435 )
• however, infertility can be rescued by liver-derived Fetuinb
impaired fertilization ( J:196435 )
• no oocytes show signs of fertilization after natural mating
• however, fertilization is restored by laser perforation of the zona pellucida barrier

cellular
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory