All Phenotypes Kdm1a<tm1.1Sho> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm1a^tm1.1Sho
targeted mutation 1.1, Stuart Orkin
MGI:5514399

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: 129 * BALB/cJ	MGI:5515313
cn2	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: 129 * BALB/cJ	MGI:5515311
cn3	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:5525153
cn4	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Tg(Mx1-cre)1Cgn/0	involves: 129 * C57BL/6 * CBA	MGI:5515309
cn5	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Tg(Mx1-cre)1Cgn/?	involves: 129 * C57BL/6 * CBA/Ca	MGI:5525154

Allelic Composition	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: 129 * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (27 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

growth/size/body

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

hematopoietic system

abnormal erythropoiesis ( J:201572 )

abnormal proerythroblast morphology ( J:201572 )

• 300% increase in CD71^hi Ter119^low proerythroblasts found in fetal liver cells

decreased fetal derived definitive erythrocyte cell number ( J:201572 )

• 20-fold decrease in number of erythrocytes found in fetal (E13.5) liver cells

reticulocytopenia ( J:201572 )

• 20-fold decrease in number of reticulocytes found in fetal (E13.5) liver cells

liver/biliary system

abnormal liver morphology ( J:201572 )

• E13.5 livers exhibit a disturbed architecture with multiple pyknotic cells displaying karyorrhexis

pale liver ( J:201572 )

• fetal liver (E13.5) is pale

Allelic Composition	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: 129 * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11a^tm1Pwt mutation (0 available); any Bcl11a mutation (44 available)
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (27 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:196140 )

• mild

decreased erythrocyte cell number ( J:196140 )

decreased hemoglobin content ( J:196140 )

Allelic Composition	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:201572 )

• hematopoietic stem and progenitor cell populations are distorted

decreased common myeloid progenitor cell number ( J:201572 )

• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)

decreased bone marrow cell number ( J:201572 )

• found in femur and tibia of 5 day old mice as compared to control

decreased erythrocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

thrombocytopenia ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

decreased hematopoietic stem cell number ( J:201572 )

• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)

immune system

decreased leukocyte cell number ( J:201572 )

• found in peripheral blood of 5 day old mice as compared to control

growth/size/body

decreased body size ( J:201572 )

• newborn pups are smaller than controls

mortality/aging

postnatal lethality, incomplete penetrance ( J:201572 )

• lethality is a result severe anemia

• most mice die by day 10

Allelic Composition	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11a^tm1Pwt mutation (0 available); any Bcl11a mutation (44 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased erythrocyte cell number ( J:196140 )

decreased hemoglobin content ( J:196140 )

decreased leukocyte cell number ( J:196140 )

immune system

decreased leukocyte cell number ( J:196140 )

Allelic Composition	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129 * C57BL/6 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal induced morbidity/mortality ( J:201572 )

• most mice die 7-10 days after final dose of the immunostimulant dsRNA poly(I:C) as compared to controls

• lethality is a result severe anemia

hematopoietic system

abnormal definitive hematopoiesis ( J:201572 )

• hematopoietic stem and progenitor cell populations are distorted following final dose of poly(I:C)

abnormal common myeloid progenitor cell morphology ( J:201572 )

• increase in numbers of bipotential granulocytic/moncytic precursor cells following final dose of poly(I:C)

• accumulation of immature myeloid cells

decreased common myeloid progenitor cell number ( J:201572 )

• decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+) after final dose of poly(I:C)

decreased granulocyte number ( J:201572 )

• Gr1^high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)

decreased neutrophil cell number ( J:201572 )

• loss of mature neutrophils following final dose of poly(I:C)

decreased hematopoietic stem cell number ( J:201572 )

• decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+) 1 week after final dose of poly(I:C)

pancytopenia ( J:201572 )

• following final dose of poly(I:C)

increased hematopoietic stem cell number ( J:201572 )

• four fold increase in long term repopulating hematopoietic stem cell (LT-HSC) population (lin- CD150+ CD48- Sca-1+ c-Kit+) found in recombined cells

• immunophenotypic LT-HSC population exhibits 2-fold proliferation, but unaltered apoptosis levels

immune system

decreased granulocyte number ( J:201572 )

• Gr1^high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)

decreased neutrophil cell number ( J:201572 )

• loss of mature neutrophils following final dose of poly(I:C)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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