Phenotypes associated with this allele

• Allele Symbol: Rad50^tm3.1Flv
• Allele Name: targeted mutation 3.1, Richard A Flavell
• Allele ID: MGI:5514423
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad50^tm3.1Flv/Rad50^tm3.1Flv	B6.129S6-Rad50^tm3.1Flv	MGI:5514499

Genotype
MGI:5514499

hm1

• Allelic Composition: Rad50^tm3.1Flv/Rad50^tm3.1Flv
• Genetic Background: B6.129S6-Rad50^tm3.1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-13 secretion ( J:196154 )

• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies

• from CD4+ T cells cultured under in vitro Th2-polarizing with anti-CD3 antibodies followed by restimulation with anti-CD3 antibodies and PMA/ionomycin in the presence of brefeldin A

• from splenocytes of mice stimulated with ovalbumin and restimulated in vitro with ovalbumin

• from skin draining lymph nodes of mice subjected to epicutaneous priming followed by restimulation with ovalbumin in the presence of splenic antibody presenting cells

decreased interleukin-4 secretion ( J:196154 )

• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies

• from CD4+ T cells cultured under in vitro Th2-polarizing with anti-CD3 antibodies followed by restimulation with anti-CD3 antibodies and PMA/ionomycin in the presence of brefeldin A

decreased interleukin-5 secretion ( J:196154 )

• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies

• from splenocytes of mice stimulated with ovalbumin and restimulated in vitro with ovalbumin

• from skin draining lymph nodes of mice subjected to epicutaneous priming followed by restimulation with ovalbumin in the presence of splenic antibody presenting cells