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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkar2btm3Gsm
targeted mutation 3, G Stanley McKnight
MGI:5515221
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prkar2btm3Gsm/Prkar2btm3Gsm B6.Cg-Prkar2btm3Gsm MGI:5515330
cn2
 		Prkar2btm3Gsm/Prkar2btm3Gsm B6.Cg-Prkar2btm3Gsm MGI:5515331
cn3
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Slc32a1tm2(cre)Lowl/Slc32a1+ 		involves: 129S6/SvEvTac * C57BL/6 MGI:5515339
cn4
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Fabp4-cre)1Rev/0 		involves: C57BL/6 MGI:5515332
cn5
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ppp1r1b-cre)1Meeh/0 		involves: C57BL/6 MGI:5515335
cn6
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Drd1tm1(cre)Rpa/Drd1+ 		involves: C57BL/6 MGI:5515336
cn7
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Syn1-cre)671Jxm/0 		involves: C57BL/6 * CBA MGI:5515333
cn8
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ins2-cre)25Mgn/0 		involves: C57BL/6 * DBA MGI:5515338
cn9
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0 		involves: C57BL/6 * FVB/N MGI:5515337
cn10
 		Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:5515334


Genotype
MGI:5515330
hm1
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic
Background		 B6.Cg-Prkar2btm3Gsm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body
decreased body weight ( J:196157 )
decreased susceptibility to diet-induced obesity ( J:196157 )

homeostasis/metabolism
increased energy expenditure ( J:196157 )
• increased energy expenditure based on total body mass when active but not based on lean body mass at rest
• energy expenditure significantly elevated during dark phase when active
increased respiratory quotient ( J:196157 )
• increased respiratory exchange rate in males in both light and dark phase
• respiratory exchange rate of females is normal

liver/biliary system

adipose tissue




Genotype
MGI:5515331
cn2
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm3Gsm
Genetic
Background		 B6.Cg-Prkar2btm3Gsm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:196157 )
• significant weight gain occurs after viral AAV1-cre-GFP is injected into the hypothalamus

adipose tissue
increased total body fat amount ( J:196157 )
• increased fat mass after viral AAV1-cre-GFP is injected into the hypothalamus




Genotype
MGI:5515339
cn3
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Slc32a1tm2(cre)Lowl mutation (2 available); any Slc32a1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• hyperactivity phenotype is reversed

growth/size/body
growth/size/body region phenotype ( J:196157 )
N
• lean body mass is similar to controls

adipose tissue
adipose tissue phenotype ( J:196157 )
N
• fat pad weights are similar to controls

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:196157 )
N
• serum leptin levels similar to controls




Genotype
MGI:5515332
cn4
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Fabp4-cre)1Rev/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Fabp4-cre)1Rev mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased locomotor activity ( J:196157 )
• hyper-locomotor activity is retained

adipose tissue
decreased gonadal fat pad weight ( J:196157 )
• reproductive fat pads weigh significantly less in both males and females

growth/size/body
decreased body weight ( J:196157 )

homeostasis/metabolism
decreased circulating leptin level ( J:196157 )
• low serum leptin levels




Genotype
MGI:5515335
cn5
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ppp1r1b-cre)1Meeh/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Ppp1r1b-cre)1Meeh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• locomotor behavior comparable to controls

growth/size/body
decreased lean body mass ( J:196157 )
• lean body weight remains low

homeostasis/metabolism
decreased circulating leptin level ( J:196157 )
• serum leptin levels remain low




Genotype
MGI:5515336
cn6
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Drd1tm1(cre)Rpa/Drd1+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm1(cre)Rpa mutation (0 available); any Drd1 mutation (70 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:196157 )
• remain hyperactive

growth/size/body
growth/size/body region phenotype ( J:196157 )
N
• body weight similar to controls

adipose tissue
adipose tissue phenotype ( J:196157 )
N
• adiposity similar to controls

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:196157 )
N
• serum leptin levels similar to controls




Genotype
MGI:5515333
cn7
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• locomotor behavior restored to normal

growth/size/body
growth/size/body region phenotype ( J:196157 )
N
• body weight restored to normal

adipose tissue
adipose tissue phenotype ( J:196157 )
N
• major fat pads are comparable to controls




Genotype
MGI:5515338
cn8
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• hyperactivity phenotype is reduced

growth/size/body
growth/size/body region phenotype ( J:196157 )
N
• body weight similar to controls
• lean body mass is similar to controls

adipose tissue
adipose tissue phenotype ( J:196157 )
N
• adiposity similar to controls

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:196157 )
N
• serum leptin levels similar to controls




Genotype
MGI:5515337
cn9
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• hyperactivity phenotype is lost

adipose tissue

growth/size/body
decreased body weight ( J:196157 )
• low body weight
• lean body

homeostasis/metabolism
decreased circulating leptin level ( J:196157 )
• low serum leptin levels




Genotype
MGI:5515334
cn10
Allelic
Composition		 Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:196157 )
N
• locomotor behavior restored to normal

growth/size/body
growth/size/body region phenotype ( J:196157 )
N
• body weight restored to normal

adipose tissue
adipose tissue phenotype ( J:196157 )
N
• major fat pads are comparable to controls




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory