Phenotypes associated with this allele

• Allele Symbol: Tsc22d3^tm1.2Efmd
• Allele Name: targeted mutation 1.2, Eric F Morand
• Allele ID: MGI:5515630
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tsc22d3^tm1.2Efmd/Y	Not Specified	MGI:5515720

Genotype
MGI:5515720

ot1

• Allelic Composition: Tsc22d3^tm1.2Efmd/Y
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:201728 )

immune system

immune system phenotype ( J:201728 )

N • LPS-treated mice induce normal serum levels of TNF, IL1B and IL6

N • in vitro thioglycollate-induced peritoneal macrophages secrete normal levels of TNF, IL1B and IL6

N • mice exhibit normal response to glucocorticoid treatment

abnormal T cell subpopulation ratio ( J:201728 )

• modest increase in the ratio of CD4+ to CD8+ T cells in the spleen

increased susceptibility to type IV hypersensitivity reaction ( J:201728 )

• mice treated with cutaneous ovalbumin exhibit increased response including increased lymph node T cell IFNgamma and IL17A production compared with wild-type mice

increased interferon-gamma secretion ( J:201728 )

• from lymph node T cell in mice treated with cutaneous ovalbumin

increased interleukin-17 secretion ( J:201728 )

• from lymph node T cell in mice treated with cutaneous ovalbumin or mBSA

abnormal susceptibility to autoimmune disorder ( J:201728 )

• in response to methylated bovine serum albumin (mBSA) within increased antigen-induced T cell activation (measured by proliferation and IFNgamma release) in lymph node cells

• however, arthritis severity induced by mBSA or K/BxN is normal

hematopoietic system

abnormal T cell subpopulation ratio ( J:201728 )

• modest increase in the ratio of CD4+ to CD8+ T cells in the spleen