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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mirc14tm1.1Ankr
targeted mutation 1.1, Andreas Krueger
MGI:5515722
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mirc14tm1.1Ankr/Mirc14tm1.1Ankr involves: C57BL/6 MGI:5515726


Genotype
MGI:5515726
hm1
Allelic
Composition
Mirc14tm1.1Ankr/Mirc14tm1.1Ankr
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc14tm1.1Ankr mutation (0 available); any Mirc14 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal thymus cellularity
• unconventional T cells population such as delta/gamma T cells and intestinal intraepithelial lymphotcytes are essentially unaffected
• slight alterations in early T lineage progenitor numbers
• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation
• reduced absolute numbers of stage 2 and stage 3 iNK T cells
• however, exogenous ligand rescues iNK T cell development beyond stage 0
• impaired agonist selection of iNK T cells
• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus
• 9-fold of iNK T cells in the spleen
• 11-fold of iNK T cells in the liver
• reduced variant NK T cells in the thymus, spleen and liver
• mild defect with slight alterations in early T lineage progenitor numbers
• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes
• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes
• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes

hematopoietic system
• slight alterations in early T lineage progenitor numbers
• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation
• reduced absolute numbers of stage 2 and stage 3 iNK T cells
• however, exogenous ligand rescues iNK T cell development beyond stage 0
• impaired agonist selection of iNK T cells
• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus
• 9-fold of iNK T cells in the spleen
• 11-fold of iNK T cells in the liver
• reduced variant NK T cells in the thymus, spleen and liver
• mild defect with slight alterations in early T lineage progenitor numbers





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory