immune system
N |
• mice exhibit normal thymus cellularity
• unconventional T cells population such as delta/gamma T cells and intestinal intraepithelial lymphotcytes are essentially unaffected
|
• slight alterations in early T lineage progenitor numbers
• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation
• reduced absolute numbers of stage 2 and stage 3 iNK T cells
• however, exogenous ligand rescues iNK T cell development beyond stage 0
|
• in frequency
|
• thymocytes
|
• impaired agonist selection of iNK T cells
|
• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus
• 9-fold of iNK T cells in the spleen
• 11-fold of iNK T cells in the liver
• reduced variant NK T cells in the thymus, spleen and liver
|
• mild defect with slight alterations in early T lineage progenitor numbers
|
• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes
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• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes
|
• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes
|
hematopoietic system
• slight alterations in early T lineage progenitor numbers
• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation
• reduced absolute numbers of stage 2 and stage 3 iNK T cells
• however, exogenous ligand rescues iNK T cell development beyond stage 0
|
• in frequency
|
• thymocytes
|
• impaired agonist selection of iNK T cells
|
• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus
• 9-fold of iNK T cells in the spleen
• 11-fold of iNK T cells in the liver
• reduced variant NK T cells in the thymus, spleen and liver
|
• mild defect with slight alterations in early T lineage progenitor numbers
|