Phenotypes associated with this allele

• Allele Symbol: Dock1^tm2.1Jfco
• Allele Name: targeted mutation 2.1, Jean-Francois Cote
• Allele ID: MGI:5515752
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-cre)7Mul/0	involves: C57BL/6 * FVB/N * FVB/NJ	MGI:5515764
cn2	Dock1^tm2.1Jfco/Dock1^tm2.1Jfco Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: C57BL/6 * FVB/NJ	MGI:5515765
cn3	Dock1^tm2.1Jfco/Dock1^+ Tg(MMTV-Erbb2*,-cre)1Mul/0	involves: C57BL/6 * FVB/NJ	MGI:5515766

Genotype
MGI:5515764

cn1

• Allelic Composition: Dock1^tm2.1Jfco/Dock1^tm2.1Jfco; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: C57BL/6 * FVB/N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:196659 )

N • mice exhibit normal mammary gland development and are capable of nursing their offspring to maturity

Genotype
MGI:5515765

cn2

• Allelic Composition: Dock1^tm2.1Jfco/Dock1^tm2.1Jfco; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

neoplasm

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

decreased metastatic potential ( J:196659 )

• 5-fold compared with Tg(MMTV-Erbb2*,-cre)1Mul mice

• all lung metastases are confined to the lung vasculature

decreased tumor growth/size ( J:196659 )

• fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• decreased proliferation and increased apoptosis in mammary gland tumors

• however, tumor angiogenesis is normal

increased tumor latency ( J:196659 )

• later onset onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

cellular

increased apoptosis ( J:196659 )

• in mammary gland tumors

decreased cell proliferation ( J:196659 )

• in mammary gland tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

integument

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

Genotype
MGI:5515766

cn3

• Allelic Composition: Dock1^tm2.1Jfco/Dock1⁺; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

neoplasm

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

increased tumor latency ( J:196659 )

• later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

integument

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:196659 )

• with later onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors