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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		4933427D14Riktm1.1(KOMP)Vlcg
targeted mutation 1.1, Velocigene
MGI:5515778
Summary 2 genotypes


Genotype
MGI:5763823
hm1
Allelic
Composition		 4933427D14Riktm1.1(KOMP)Vlcg/4933427D14Riktm1.1(KOMP)Vlcg
Genetic
Background		 B6N(Cg)-4933427D14Riktm1.1(KOMP)Vlcg/J
Cell Lines 18550A-G4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
4933427D14Riktm1.1(KOMP)Vlcg mutation (1 available); any 4933427D14Rik mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

4933427D14Riktm1.1(KOMP)Vlcg/4933427D14Riktm1.1(KOMP)Vlcg mice exhibit embryonic lethality embryos recovered at E7.5 but not at E9.5. Embryos exhibit abnormal embryo turning and growth retardation at E8.5.

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• homozygous embryos are recovered in expected ratios at E7.5 but found dead at E9.5

embryo
abnormal embryo turning ( J:279207 )
• embryos fail to properly turn
embryonic growth retardation ( J:279207 )
• embryos are significantly delayed at E8.5
• however, most morphological features typical of E7.5 and E8.5 are present
decreased embryo size ( J:279207 )
• embryos appear slightly smaller than controls at E7.5

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos are significantly delayed at E8.5
• however, most morphological features typical of E7.5 and E8.5 are present
decreased embryo size ( J:279207 )
• embryos appear slightly smaller than controls at E7.5




Genotype
MGI:7783571
hm2
Allelic
Composition		 4933427D14Riktm1.1(KOMP)Vlcg/4933427D14Riktm1.1(KOMP)Vlcg
Genetic
Background		 C57BL/6N-4933427D14Riktm1.1(KOMP)Vlcg/JMmucd
Cell Lines 18550A-G4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
4933427D14Riktm1.1(KOMP)Vlcg mutation (1 available); any 4933427D14Rik mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal heart looping ( J:307969 )
• E9.5 embryos display unlooped, midline hearts
pericardial edema ( J:307969 )
• E9.5 embryos display pericardial edema

embryo
decreased embryonic neuroepithelium primary cilium number ( J:307969 )
• although CEP43 (FOP)-positive centrioles are detected, no ARL13-positive cilia are present in neural tube sections at E9.5

cellular
abnormal primary cilium morphology ( J:307969 )
• when serum-starved for 24 h, MEFs derived from E8.5 embryos possess centrioles but exhibit complete loss of cilia, unlike control MEFs
• serum-starved MEFs fail to show induction of the Hedgehog target genes Gli1 and Ptch1 in response to the Hedgehog pathway activator Smoothened agonist (SAG), unlike control MEFs
decreased embryonic neuroepithelium primary cilium number ( J:307969 )
• although CEP43 (FOP)-positive centrioles are detected, no ARL13-positive cilia are present in neural tube sections at E9.5

homeostasis/metabolism
pericardial edema ( J:307969 )
• E9.5 embryos display pericardial edema

nervous system
decreased embryonic neuroepithelium primary cilium number ( J:307969 )
• although CEP43 (FOP)-positive centrioles are detected, no ARL13-positive cilia are present in neural tube sections at E9.5




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory