Phenotypes associated with this allele

• Allele Symbol: Chuk^tm2Yhu
• Allele Name: targeted mutation 2, Yinling Hu
• Allele ID: MGI:5515790
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chuk^tm2Yhu/Chuk^tm2Yhu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5515881
hm2	Chuk^tm2Yhu/Chuk^tm2Yhu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5515802
hm3	Chuk^tm2Yhu/Chuk^tm2Yhu	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5515880
cx4	Chuk^tm2Yhu/Chuk^tm2Yhu Tg(Lor-CHUK)8Yhu/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5515883
cx5	Chuk^tm2Yhu/Chuk^tm2Yhu Tg(Lor-CHUK)8Yhu/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5515882
cx6	Chuk^tm2Yhu/Chuk^tm2Yhu Tg(KRT5-CHUK)#Yhu/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5515884

Genotype
MGI:5515881

hm1

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte proliferation ( J:197037 )

• at more than 3 months of age in the epidermis

increased skin squamous cell carcinoma incidence ( J:197037 )

• in some mice at 5 to10 months of age

digestive/alimentary system

esophagus hyperplasia ( J:197037 )

• esophageal hyperplasia in all three mice at 1.2 years of age

neoplasm

increased skin squamous cell carcinoma incidence ( J:197037 )

• in some mice at 5 to10 months of age

cellular

increased keratinocyte proliferation ( J:197037 )

• at more than 3 months of age in the epidermis

growth/size/body

esophagus hyperplasia ( J:197037 )

• esophageal hyperplasia in all three mice at 1.2 years of age

Genotype
MGI:5515802

hm2

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

integument

integument phenotype ( J:201799 )

N • mice exhibit normal skin development

Genotype
MGI:5515880

hm3

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:197037 )

• mice begin to die after 6 to 10 months

integument

skin inflammation ( J:197037 )

• after 3 months

skin lesions ( J:197037 )

• severe after 3 months

neoplasm

increased lung tumor incidence ( J:197037 )

• from 4 to 10 months of age

immune system

skin inflammation ( J:197037 )

• after 3 months

respiratory system

increased lung tumor incidence ( J:197037 )

• from 4 to 10 months of age

Genotype
MGI:5515883

cx4

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(Lor-CHUK)8Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

immune system

increased neutrophil cell number ( J:197037 )

• moderate in the lungs

increased CD4-positive, alpha-beta T cell number ( J:197037 )

• in the lungs

increased CD8-positive, alpha-beta T cell number ( J:197037 )

• moderate in the lungs

increased macrophage cell number ( J:197037 )

• extensive macrophage infiltration into squamous cell carcinoma

lung inflammation ( J:197037 )

• with increased oxidant

• however, macrophage depletions reduces inflammation

respiratory system

lung inflammation ( J:197037 )

• with increased oxidant

• however, macrophage depletions reduces inflammation

neoplasm

increased squamous cell carcinoma incidence ( J:197037 )

• in 2 of 3 mice at 1.2 years of age in the forestomach

• bone marrow reconstitutes lung SCCs in irradiated mice

• however, macrophage depletion prevents SCC development

digestive/alimentary system

stomach mucosa hyperplasia ( J:197037 )

• atypical squamous hyperplasia in the forestomach in all mice at 5 months to 1.2 years

• however, macrophage depletion reduces epithelial proliferation

hematopoietic system

increased neutrophil cell number ( J:197037 )

• moderate in the lungs

increased CD4-positive, alpha-beta T cell number ( J:197037 )

• in the lungs

increased CD8-positive, alpha-beta T cell number ( J:197037 )

• moderate in the lungs

increased macrophage cell number ( J:197037 )

• extensive macrophage infiltration into squamous cell carcinoma

Genotype
MGI:5515882

cx5

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(Lor-CHUK)8Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:197037 )

• mice do not live longer than 7 or 8 months

neoplasm

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

respiratory system

enlarged lung ( J:197037 )

• associated with tumor development

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

immune system

absent lymph nodes ( J:197037 )

integument

integument phenotype ( J:197037 )

N • mice do not develop skin phenotype observed in Chuk^tm2Yhu homozygotes

growth/size/body

enlarged lung ( J:197037 )

• associated with tumor development

Genotype
MGI:5515884

cx6

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(KRT5-CHUK)#Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

mortality/aging ( J:197037 )

N • mice survive longer than Chuk^tm2Yhu/Chuk^tm2Yhu Tg(Lor-CHUK)8Yhu mice

neoplasm

neoplasm ( J:197037 )

N • mice do not develop lung tumors at more than 1 year of age