Phenotypes associated with this allele

• Allele Symbol: Brap^tm1.1Yfng
• Allele Name: targeted mutation 1.1, Yuanyi Feng
• Allele ID: MGI:5515812
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brap^tm1.1Yfng/Brap^tm1.1Yfng	involves: C57BL/6 * FVB/N	MGI:5515912
cx2	Brap^tm1.1Yfng/Brap^tm1.1Yfng Pafah1b1^tm1Awb/Pafah1b1^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5515911

Genotype
MGI:5515912

hm1

• Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:197131 )

• survive to E12 but die before E13

growth/size/body

growth/size/body region phenotype ( J:197131 )

N • little difference in size and morphology from controls

cellular

abnormal mitosis ( J:197131 )

• subtle differences in interkinetic nuclear migration

• about 85% of neuron progenitors with metaphase chromosomes properly positioned

Genotype
MGI:5515911

cx2

• Allelic Composition: Brap^tm1.1Yfng/Brap^tm1.1Yfng; Pafah1b1^tm1Awb/Pafah1b1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

mortality/aging

embryonic lethality during organogenesis ( J:197131 )

• lethality around E11.5

growth/size/body

decreased embryo size ( J:197131 )

nervous system

abnormal roof plate morphology ( J:197131 )

• roof plate widening

cellular

abnormal mitosis ( J:197131 )

• less than 60% of neuron progenitors with properly positioned metaphase chromosomes

embryo

decreased embryo size ( J:197131 )

abnormal roof plate morphology ( J:197131 )

• roof plate widening