Phenotypes associated with this allele

• Allele Symbol: Rhbdd3^tm1Caox
• Allele Name: targeted mutation 1, Xuetao Cao
• Allele ID: MGI:5516031
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbdd3^tm1Caox/Rhbdd3^tm1Caox	B6.129S6-Rhbdd3^tm1Caox	MGI:5516032

Genotype
MGI:5516032

hm1

• Allelic Composition: Rhbdd3^tm1Caox/Rhbdd3^tm1Caox
• Genetic Background: B6.129S6-Rhbdd3^tm1Caox

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells rescues phenotype

immune system

immune system phenotype ( J:197348 )

N • normal distributions of B cells, T cells, NK cells and myeloid cells

increased NK cell number ( J:197348 )

• in the liver after pIpC challenge

increased natural killer cell mediated cytotoxicity ( J:197348 )

• when NK cells are stimulated with pIpC then cultured with 5,6-carboxyfluorescein diacetate succinimidyl ester-labeled Yac-1 cells

increased circulating interferon-gamma level ( J:197348 )

• in pIpC-treated mice

increased circulating interleukin-6 level ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells partially rescues phenotype

abnormal dendritic cell physiology ( J:197348 )

• dendritic cells mediate elevated activation of NK cells by pIpC stimulation compared with wild-type cells

increased interferon-gamma secretion ( J:197348 )

• upon pIpC stimulation of splenocytes

• from pIpC-treated NK cells

• however, secretion following IL12/25-stimulation is normal

• however, NK cell secretion is normal in a Transwell system

increased interleukin-6 secretion ( J:197348 )

• upon pIpC stimulation of splenocytes

• in the liver of pIpC-treated mice

• however, secretion following IL12/25-stimulation is normal

liver inflammation ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells rescues phenotype

liver/biliary system

liver inflammation ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells rescues phenotype

hepatic necrosis ( J:197348 )

• in pIpC-treated mice

homeostasis/metabolism

increased circulating interferon-gamma level ( J:197348 )

• in pIpC-treated mice

increased circulating interleukin-6 level ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells partially rescues phenotype

increased circulating alanine transaminase level ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells rescues phenotype

increased circulating aspartate transaminase level ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK or Kupffer cells rescues phenotype

increased susceptibility to xenobiotic induced morbidity/mortality ( J:197348 )

• in pIpC-treated mice

• however, depletion of NK cells rescues phenotype

hematopoietic system

increased NK cell number ( J:197348 )

• in the liver after pIpC challenge

increased natural killer cell mediated cytotoxicity ( J:197348 )

• when NK cells are stimulated with pIpC then cultured with 5,6-carboxyfluorescein diacetate succinimidyl ester-labeled Yac-1 cells