Phenotypes associated with this allele

• Allele Symbol: Mrm3^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5516076
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrm3^tm1.1(KOMP)Vlcg/Mrm3^tm1.1(KOMP)Vlcg	B6N(Cg)-Mrm3^tm1.1(KOMP)Vlcg/J	MGI:5757650
ht2	Mrm3^tm1.1(KOMP)Vlcg/Mrm3^+	B6N(Cg)-Mrm3^tm1.1(KOMP)Vlcg/J	MGI:5759439

Genotype
MGI:5757650

hm1

• Allelic Composition: Mrm3^{tm1.1(KOMP)Vlcg}/Mrm3^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Mrm3^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13785A-E7

Data Sources

IMPC Data for Mrm3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mrm3^{tm1.1(KOMP)Vlcg}/Mrm3^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos show embryonic growth retardation and stall in development around E8.0.

embryo

embryonic growth retardation ( J:279207 )

• embryos stall in development at ~E8.0 and are significantly delayed by E8.5

• however, most morphological features typical of E7.5 are present

decreased embryo size ( J:279207 )

• embryos appear slightly smaller than controls at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos stall in development at ~E8.0 and are significantly delayed by E8.5

• however, most morphological features typical of E7.5 are present

decreased embryo size ( J:279207 )

• embryos appear slightly smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• homozygous embryos are recovered in expected Mendelian ratios at E7.5 but stall in development at ~E8.0; no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5759439

ht2

• Allelic Composition: Mrm3^{tm1.1(KOMP)Vlcg}/Mrm3⁺
• Genetic Background: B6N(Cg)-Mrm3^{tm1.1(KOMP)Vlcg}/J
• Cell Lines: 13785A-E7

Data Sources

IMPC Data for Mrm3

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - JAX