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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc4a9tm1Doel
targeted mutation 1, Dominique Eladari
MGI:5516078
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc4a9tm1Doel/Slc4a9tm1Doel involves: 129 * C57BL/6 MGI:5516081


Genotype
MGI:5516081
hm1
Allelic
Composition		 Slc4a9tm1Doel/Slc4a9tm1Doel
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a9tm1Doel mutation (0 available); any Slc4a9 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal reabsorption ( J:197347 )
• cortical collecting ducts exhibit reduced sodium dependent intracellular pH changes independently of the presence or absence of sodium bicarbonate ion cotransport compared with wild-type cells
• cortical collecting duct fail to exhibit amiloride-resistant sodium and chloride ion absorption due to defective basolateral sodium bicarbonate ion cotransport unlike wild-type cells
• however, sodium-dependent bicarbonate flux is not fully abolished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory