Phenotypes associated with this allele

• Allele Symbol: Pdcl^tm1.1Bmw
• Allele Name: targeted mutation 1.1, Barry M Willardson
• Allele ID: MGI:5516193
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdcl^tm1.1Bmw/Pdcl^tm1.1Bmw Tg(Rho-icre)1Ck/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5516349

Genotype
MGI:5516349

cn1

• Allelic Composition: Pdcl^tm1.1Bmw/Pdcl^tm1.1Bmw; Tg(Rho-icre)1Ck/0
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina photoreceptor morphology ( J:197148 )

short retina rod cell outer segment ( J:197148 )

• about 25% shortening of outer segments relative to controls at 35 days

• the very few rods remaining at 6 months are malformed with almost no outer segment

retina photoreceptor degeneration ( J:197148 )

• progressive photoreceptor degeneration

retina rod cell degeneration ( J:197148 )

• no loss at 1 month

• definite losses at 2 months

• half of nuclei are lost by 3-4 months

• almost all nuclei are lost by 9 months

abnormal eye physiology ( J:197148 )

photosensitivity ( J:197148 )

• reduced response to light flashes

• twelve fold increase in light intensity required for a 1/2 saturating response

abnormal electroretinogram waveform feature ( J:197148 )

• considerable reduction in light sensitivity and response amplitude

• seventeen fold desensitization for the a-wave and a two fold reduction in maximal response

• 25% decrease in response amplitude

• 3.8 fold reduction in signal amplification rate

• substantially decelerated falling phase

decreased visual acuity ( J:197148 )

• 3 fold reduction in visual acuity under dim lighting

• visual acuity is normal under bright lights

delayed dark adaptation ( J:197148 )

• recovery time constant is increased five fold

nervous system

abnormal retina photoreceptor morphology ( J:197148 )

short retina rod cell outer segment ( J:197148 )

• about 25% shortening of outer segments relative to controls at 35 days

• the very few rods remaining at 6 months are malformed with almost no outer segment

retina photoreceptor degeneration ( J:197148 )

• progressive photoreceptor degeneration

retina rod cell degeneration ( J:197148 )

• no loss at 1 month

• definite losses at 2 months

• half of nuclei are lost by 3-4 months

• almost all nuclei are lost by 9 months

homeostasis/metabolism

photosensitivity ( J:197148 )

• reduced response to light flashes

• twelve fold increase in light intensity required for a 1/2 saturating response