All Phenotypes Hfe<tm1.1Jrco> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hfe^tm1.1Jrco
targeted mutation 1.1, James Connor
MGI:5516426

Summary

2 genotypes

Allelic Composition	Hfe^tm1.1Jrco/Hfe^tm1.1Jrco
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Jrco mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal brain iron level ( J:201948 )

• in the cortex, hippocampus and the cerebellum at 6, but not 12, months

increased liver iron level ( J:201948 )

• at 6 and 12 months

nervous system

abnormal brain iron level ( J:201948 )

• in the cortex, hippocampus and the cerebellum at 6, but not 12, months

astrocytosis ( J:201948 )

growth/size/body

increased body weight ( J:201948 )

• at 6 and 12 months

cellular

oxidative stress ( J:201948 )

• at 6, but not 12, months

liver/biliary system

increased liver iron level ( J:201948 )

• at 6 and 12 months

Allelic Composition	Hfe^tm1.1Jrco/Hfe⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfe^tm1.1Jrco mutation (0 available); any Hfe mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oxidative stress ( J:201948 )

• at 6, but not 12, months

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24